ZNF384

Protein identityUniProt · HPA

UniProt accession

Q8TF68

Gene

ZNF384

Ensembl

ENSG00000126746

Chromosome

12

Canonical length

577 aa

Protein class

Cancer-related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q8TF68|ZNF384
     1  MEESHFNSNP YFWPSIPTVS GQIENTMFIN KMKDQLLPEK GCGLAPPHYP TLLTVPASVS
    61  LPSGISMDTE SKSDQLTPHS QASVTQNITV VPVPSTGLMT AGVSCSQRWR REGSQSRGPG
   121  LVITSPSGSL VTTASSAQTF PISAPMIVSA LPPGSQALQV VPDLSKKVAS TLTEEGGGGG
   181  GGGGSVAPKP PRGRKKKRML ESGLPEMNDP YVLSPEDDDD HQKDGKTYRC RMCSLTFYSK
   241  SEMQIHSKSH TETKPHKCPH CSKTFANSSY LAQHIRIHSG AKPYSCNFCE KSFRQLSHLQ
   301  QHTRIHSKMH TETIKPHKCP HCSKTFANTS YLAQHLRIHS GAKPYNCSYC QKAFRQLSHL
   361  QQHTRIHTGD RPYKCAHPGC EKAFTQLSNL QSHRRQHNKD KPFKCHNCHR AYTDAASLEV
   421  HLSTHTVKHA KVYTCTICSR AYTSETYLMK HMRKHNPPDL QQQVQAAAAA AAVAQAQAQA
   481  QAQAQAQAQA QAQAQASQAS QQQQQQQQQQ QQQQQQPPPH FQSPGAAPQG GGGGDSNPNP
   541  PPQCSFDLTP YKTAEHHKDI CLTVTTSTIQ VEHLASS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF384 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.58

Highest tissue expression

56 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

gnomAD missense Z

2.44

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• Zinc finger protein, C2H2-type
• Zinc finger, C2H2 type

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Phosphoprotein
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF384 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BCAR1