Seroatlas · Human Serome Atlas

ZNF33A

Zinc finger protein 33A

Also known as: FLJ23404, KIAA0065, KOX31, KOX5, ZN33A_HUMAN, ZNF11A, ZNF33, ZZAPK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q06730
Gene: ZNF33A
Ensembl: ENSG00000189180
Chromosome: 10
Canonical length: 810 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center,Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

810 residues, UniProt reviewed canonical sequence.

>Q06730|ZNF33A
     1  MNKVEQKSQE SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS VGYCVHKPEV
    61  IFRLQQGEEP WKQEEEFPSQ SFPVWTADHL KERSQENQSK HLWEVVFINN EMLTKEQGDV
   121  IGIPFNVDVS SFPSRKMFCQ CDSCGMSFNT VSELVISKIN YLGKKSDEFN ACGKLLLNIK
   181  HDETHTQEKN EVLKNRNTLS HHEETLQHEK IQTLEHNFEY SICQETLLEK AVFNTQKREN
   241  AEENNCDYNE FGRTLCDSSS LLFHQISPSR DNHYEFSDCE KFLCVKSTLS KPHGVSMKHY
   301  DCGESGNNFR RKLCLSHLQK GDKGEKHFEC NECGKAFWEK SHLTRHQRVH TGQKPFQCNE
   361  CEKAFWDKSN LTKHQRSHTG EKPFECNECG KAFSHKSALT LHQRTHTGEK PYQCNACGKT
   421  FCQKSDLTKH QRTHTGLKPY ECYECGKSFR VTSHLKVHQR THTGEKPFEC LECGKSFSEK
   481  SNLTQHQRIH IGDKSYECNA CGKTFYHKSL LTRHQIIHTG WKPYECYECG KTFCLKSDLT
   541  VHQRTHTGQK PFACPECGKF FSHKSTLSQH YRTHTGEKPY ECHECGKIFY NKSYLTKHNR
   601  THTGEKPYEC NECGKAFYQK SQLTQHQRIH IGEKPYKCNE CGKAFCHKSA LIVHQRTHTQ
   661  EKPYKCNECG KSFCVKSGLI FHERKHTGEK PYECNECGKF FRHKSSLTVH HRAHTGEKSC
   721  QCNECGKIFY RKSELAQHQR SHTGEKPYEC NTCRKTFSQK SNLIVHQRRH IGENLMNEMD
   781  IRNFQPQVSL HNASEYSHCG ESPDDILNVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF33A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 19 nTPM
retina: 19 nTPM
breast: 17 nTPM
parathyroid gland: 16 nTPM
pancreas: 16 nTPM
stomach: 16 nTPM

Single-cell type

neutrophils: 385 nCPM
neutrophil progenitors: 323 nCPM
lactotrophs: 279 nCPM
somatotrophs: 268 nCPM
thyrotrophs: 235 nCPM
corticotrophs: 221 nCPM

Immune cell

neutrophil: 16 nTPM
basophil: 13 nTPM
non-classical monocyte: 6.6 nTPM
memory B-cell: 6.4 nTPM
naive B-cell: 6.2 nTPM
plasmacytoid DC: 6.2 nTPM

Brain region

cerebellum: 42 nTPM
pons: 27 nTPM
choroid plexus: 27 nTPM
white matter: 23 nTPM
medulla oblongata: 23 nTPM
hypothalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF33A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAP3K20

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF33A as an antibody target. Whether an autoantibody or antibody against ZNF33A could matter depends on whether native ZNF33A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF33A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF33A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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