Seroatlas · Human Serome Atlas

ZNF32

Zinc finger protein 32

Also known as: KOX30, Zfp637, ZNF32_HUMAN, ZNF637

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17041
Gene: ZNF32
Ensembl: ENSG00000169740
Chromosome: 10
Canonical length: 273 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>P17041|ZNF32
     1  MFGFPTATLL DCHGRYAQNV AFFNVMTEAH HKYDHSEATG SSSWDIQNSF RREKLEQKSP
    61  DSKTLQEDSP GVRQRVYECQ ECGKSFRQKG SLTLHERIHT GQKPFECTHC GKSFRAKGNL
   121  VTHQRIHTGE KPYQCKECGK SFSQRGSLAV HERLHTGQKP YECAICQRSF RNQSNLAVHR
   181  RVHSGEKPYR CDQCGKAFSQ KGSLIVHIRV HTGLKPYACT QCRKSFHTRG NCILHGKIHT
   241  GETPYLCGQC GKSFTQRGSL AVHQRSCSQR LTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 79 nTPM
tongue: 68 nTPM
heart muscle: 56 nTPM
midbrain: 56 nTPM
amygdala: 55 nTPM
epididymis: 54 nTPM

Single-cell type

decidual stromal cells: 59 nCPM
epididymal principal cells: 54 nCPM
smooth muscle cells: 53 nCPM
ovarian stromal cells: 53 nCPM
epididymal clear cells: 51 nCPM
peritubular myoid cells: 51 nCPM

Immune cell

NK-cell: 51 nTPM
naive CD8 T-cell: 42 nTPM
memory CD8 T-cell: 41 nTPM
naive CD4 T-cell: 37 nTPM
MAIT T-cell: 37 nTPM
gdT-cell: 37 nTPM

Brain region

white matter: 32 nTPM
basal ganglia: 30 nTPM
medulla oblongata: 29 nTPM
thalamus: 29 nTPM
cerebellum: 29 nTPM
midbrain: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.03
gnomAD missense Z: 1.42
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PARP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF32 as an antibody target. Whether an autoantibody or antibody against ZNF32 could matter depends on whether native ZNF32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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