Seroatlas · Human Serome Atlas

ZNF318

Zinc finger protein 318

Also known as: HRIHFB2436, ZFP318, ZN318_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VUA4
Gene: ZNF318
Ensembl: ENSG00000171467
Chromosome: 6
Canonical length: 2279 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2279 residues, UniProt reviewed canonical sequence.

>Q5VUA4|ZNF318
     1  MYRSSARSSV SSHRPKDDGG GGPRSGRSSG SSSGPARRSS PPPPPSGSSS RTPARRPRSP
    61  SGHRGRRASP SPPRGRRVSP SPPRARRGSP SPPRGRRLFP PGPAGFRGSS RGESRADYAR
   121  DGRGDHPGDS GSRRRSPGLC SDSLEKSLRI TVGNDHFCVS TPERRRLSDR LGSPVDNLED
   181  MDRDDLTDDS VFTRSSQCSR GLERYISQEE GPLSPFLGQL DEDYRTKETF LHRSDYSPHI
   241  SCHDELLRGT ERNREKLKGY SIRSEERSRE AKRPRYDDTV KINSMGGDHP SFTSGTRNYR
   301  QRRRSPSPRF LDPEFRELDL ARRKREEEEE RSRSLSQELV GVDGGGTGCS IPGLSGVLTA
   361  SEPGYSLHRP EEVSVMPKKS ILKKRIEVDI MEPSMQLESF SSSTSSSQDH PLYSGHPSLP
   421  LSGAIAAFAS EIENKGTMVE TALKEPQGNL YQWGPLPGIP KDNSPLREKF GSFLCHKDNL
   481  DLKAEGPERH TDFLLPHERA SQDGSGFSRI LSMLADSTST QEKRRRSFPD IEDEEKFLYG
   541  DEEEDLKAES VPKPLGSSES EVMRQKASSL PSSAPAVKLE SLEETNPEYA KIHDLLKTIG
   601  LDIGVAEISQ LAARTQERLH GKKPSLRSSA DRRSSVDRYF SADHCSSVDH RFSADRCSSV
   661  DHCFSADRRS SDPHRLESRE AHHSNTHSPE VSHPHPPSPV DPYLLTKNSP PFLKSDHPVG
   721  HISGPEVVGS GFQSSVAVRC MLPSAPSAPI RLPHTAALSQ FHMPRASQFA AARIPPNYQG
   781  PAIPPASFDA YRHYMAYAAS RWPMYPTSQP SNHPVPEPHR IMPITKQATR SRPNLRVIPT
   841  VTPDKPKQKE SLRGSIPAAQ VPVQVSIPSL IRYNPEKISD EKNRASQKQK VIEEREKLKN
   901  DREARQKKMY YLRTELERLH KQQGEMLRKK RREKDGHKDP LLVEVSRLQD NIMKDIAELR
   961  QEAEEAEKKQ SELDKVAQIL GINIFDKSQK SLSDSREPTE KPGKAEKSKS PEKVSSFSNS
  1021  SSNKESKVNN EKFRTKSPKP AESPQSATKQ LDQPTAAYEY YDAGNHWCKD CNTICGTMFD
  1081  FFTHMHNKKH TQTLDPYNRP WASKTQSEAK QDAIKRTDKI TVPAKGSEFL VPISGFYCQL
  1141  CEEFLGDPIS GEQHVKGHQH NEKYKKYVDE NPLYEERRNL DRQAGLAVVL ETERRRQSEL
  1201  KRKLSEKPKE EKKEKKAKAV KEVKEDDKVS EKLEDQLSEG RNSPEKAENK RNTGIKLQLK
  1261  EEVKKESPTS SSFGKFSWKK PEKEEEKSSL VTPSISKEEI LESSKDKEDG KTEAGKAKPI
  1321  KIKLSGKTVV AHTSPWMPVV TTSTQTKIRP NLPIPSTVLR KSCSATMSKP APLNTFLSIK
  1381  SSGTTAKPLP VVKESSADLL LPPDIISKAF GGEEVILKGS PEEKVVLAEK SEPSHLPEQI
  1441  LPPPPPPPPP PPPPPPVIPH PAAPSAAQAN AILAPVKSNP VVSQTLSPGF VGPNILNPVL
  1501  PVAIMASAQP AAIPSDETAP GVSESDRDQT LFSVLVRPPP PLSSVFSEQA KKLEKRNSCL
  1561  ATANAKDLYD IFYSSGGKGA PETKGAPETK LSGGPLANGE NSNLSRTKSS DTSSTSPLNS
  1621  SASQEELHQD EGLVAAPIVS NSEKPIAKTL VALGKWSVVE HVGPKSTGST YGFLQPLTRL
  1681  CQSRPYETIT PKTDTLAIWT SSSFQSDTSR DISPEKSELD LGEPGPPGVE PPPQLLDIQC
  1741  KESQKLVEIH LRESVNQDKE SQELRKSEDC RESEIETNTE LKERVKELSE GIVDEGVSTS
  1801  IGPHSIDDSN LNHGNRYMWE GEVKQPNLLM IDKEAEQSNK LMTGSETPSK VVIKLSPQAC
  1861  SFTKAKLDSF LSEARSLLNP QDTPVKISAP ELLLHSPARS AMCLTGSPQE QGVSVVSEEG
  1921  LENSAPESAS RTSRYRSLKL KRERSKDFQV KKIYELAVWD ENKKRPETWE SPEKPKTEAL
  1981  ELQDVHPELT VTIESKALED FEATDLKVEE LTALGNLGDM PVDFCTTRVS PAHRSPTVLC
  2041  QKVCEENSVS PIGCNSSDPA DFEPIPSFSG FPLDSPKTLV LDFETEGERN SPNPRSVRIP
  2101  SPNILKTGLT ENVDRGLGGL EGTHQALDLL AGGMMPEEVK ESSQLDKQES LGLELKTINS
  2161  AGLGPSPCLP DLVDFVTRTS GVQKDKLCSP LSEPGDPSKC SSLELGPLQL EISNASTTEV
  2221  AILQVDDDSG DPLNLVKAPV SRSPPREQVI EDNMVPQGMP EQETTVGAIQ DHTESSVHN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF318 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
lymph node: 24 nTPM
tonsil: 23 nTPM
retina: 20 nTPM
spleen: 14 nTPM
cervix: 13 nTPM

Single-cell type

early primary spermatocytes: 121 nCPM
late primary spermatocytes: 92 nCPM
b-cells: 76 nCPM
oligodendrocyte progenitor cells: 74 nCPM
bergmann glia: 72 nCPM
brain excitatory neurons: 62 nCPM

Immune cell

naive B-cell: 2.1 nTPM
memory B-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
T-reg: 0.5 nTPM
memory CD4 T-cell: 0.4 nTPM
classical monocyte: 0.3 nTPM

Brain region

cerebellum: 35 nTPM
cerebral cortex: 25 nTPM
white matter: 25 nTPM
amygdala: 24 nTPM
hippocampal formation: 22 nTPM
basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.37
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Matrin/U1-C-like, C2H2-type zinc finger
Zinc finger protein 318-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF318 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF318 as an antibody target. Whether an autoantibody or antibody against ZNF318 could matter depends on whether native ZNF318 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF318 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF318 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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