Seroatlas · Human Serome Atlas

ZNF317

Zinc finger protein 317

Also known as: ZN317_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PQ6
Gene: ZNF317
Ensembl: ENSG00000130803
Chromosome: 19
Canonical length: 595 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q96PQ6|ZNF317
     1  MAALSPTFAT STQDSTCLQD SEFPVSSKDH SCPQNLDLFV CSGLEPHTPS VGSQESVTFQ
    61  DVAVDFTEKE WPLLDSSQRK LYKDVMLENY SNLTSLGYQV GKPSLISHLE QEEEPRTEER
   121  GAHQGACADW ETPSKTKWSL LMEDIFGKET PSGVTMERAG LGEKSTEYAH LFEVFGMDPH
   181  LTQPMGRHAG KRPYHRRDYG VAFKGRPHLT QHMSMYDGRK MHECHQCQKA FTTSASLTRH
   241  RRIHTGEKPY ECSDCGKAFN DPSALRSHAR THLKEKPFDC SQCGNAFRTL SALKIHMRVH
   301  TGERPYKCDQ CGKAYGRSCH LIAHKRTHTG ERPYECHDCG KAFQHPSHLK EHVRNHTGEK
   361  PYACTQCGKA FRWKSNFNLH KKNHMVEKTY ECKECGKSFG DLVSRRKHMR IHIVKKPVEC
   421  RQCGKTFRNQ SILKTHMNSH TGEKPYGCDL CGKAFSASSN LTAHRKIHTQ ERRYECAACG
   481  KVFGDYLSRR RHMSVHLVKK RVECRQCGKA FRNQSTLKTH MRSHTGEKPY ECDHCGKAFS
   541  IGSNLNVHRR IHTGEKPYEC LVCGKAFSDH SSLRSHVKTH RGEKLFVSSV WKRLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF317 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 25 nTPM
spleen: 24 nTPM
skin: 22 nTPM
liver: 21 nTPM
kidney: 20 nTPM
cerebellum: 19 nTPM

Single-cell type

tuft cells: 46 nCPM
erythrocyte progenitors: 26 nCPM
megakaryocyte-erythroid progenitors: 24 nCPM
microglia: 22 nCPM
b-cells: 21 nCPM
pancreatic acinar cells: 20 nCPM

Immune cell

NK-cell: 23 nTPM
T-reg: 23 nTPM
memory B-cell: 21 nTPM
MAIT T-cell: 21 nTPM
basophil: 19 nTPM
naive CD8 T-cell: 18 nTPM

Brain region

cerebral cortex: 15 nTPM
white matter: 15 nTPM
cerebellum: 15 nTPM
choroid plexus: 15 nTPM
thalamus: 14 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 1.33
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF317 as an antibody target. Whether an autoantibody or antibody against ZNF317 could matter depends on whether native ZNF317 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF317 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF317 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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