Seroatlas · Human Serome Atlas

ZNF304

Zinc finger protein 304

Also known as: ZN304_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCX3
Gene: ZNF304
Ensembl: ENSG00000131845
Chromosome: 19
Canonical length: 659 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein functions as a transcriptional repressor that recruits a corepressor complex to stimulate promoter hypermethylation and transcriptional silencing of target genes. Expression of this gene is upregulated in colorectal, ovarian and breast cancer, and this gene may promote cancer cell survival, growth and invasion. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

659 residues, UniProt reviewed canonical sequence.

>Q9HCX3|ZNF304
     1  MAAAVLMDRV QSCVTFEDVF VYFSREEWEL LEEAQRFLYR DVMLENFALV ATLGFWCEAE
    61  HEAPSEQSVS VEGVSQVRTA ESGLFQKAHP CEMCDPLLKD ILHLAEHQGS HLTQKLCTRG
   121  LCRRRFSFSA NFYQHQKQHN GENCFRGDDG GASFVKSCTV HMLGRSFTCR EEGMDLPDSS
   181  GLFQHQTTYN RVSPCRRTEC MESFPHSSSL RQHQGDYDGQ MLFSCGDEGK AFLDTFTLLD
   241  SQMTHAEVRP FRCLPCGNVF KEKSALINHR KIHSGEISHV CKECGKAFIH LHHLKMHQKF
   301  HTGKRHYTCS ECGKAFSRKD TLVQHQRVHT GERSYDCSEC GKAYSRSSHL VQHQRIHTGE
   361  RPYKCNKCGK AFSRKDTLVQ HQRFHTGERP YECSECGKFF SQSSHLIEHW RIHTGARPYE
   421  CIECGKFFSH NSSLIKHRRV HTGARSYVCS KCGKAFGCKD TLVQHQIIHT GARPYECSEC
   481  GKAFSRKDTL VQHQKIHTGE RPYECGECGK FFSHSSNLIV HQRIHTGAKP YECNECGKCF
   541  SHNSSLILHQ RVHTGARPYV CSECGKAYIS SSHLVQHKKV HTGARPYECS ECGKFFSRNS
   601  GLILHQRVHT GEKPYVCSEC GKAYSRSSHL VRHQKAHTGE RAHECNSFGG PLAASLKLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF304 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 9.4 nTPM
cerebellum: 8.6 nTPM
epididymis: 7 nTPM
thymus: 7 nTPM
tonsil: 6.8 nTPM
thyroid gland: 6.6 nTPM

Single-cell type

retinal ganglion cells: 12 nCPM
breast hormone-responsive cells: 11 nCPM
innate lymphoid cells: 8.9 nCPM
parietal cells: 8.8 nCPM
ocular epithelial cells: 8.3 nCPM
retinal amacrine cells: 8.2 nCPM

Immune cell

NK-cell: 2.8 nTPM
non-classical monocyte: 2.8 nTPM
MAIT T-cell: 2.6 nTPM
basophil: 2.5 nTPM
memory CD4 T-cell: 2.4 nTPM
memory B-cell: 2.3 nTPM

Brain region

cerebellum: 14 nTPM
cerebral cortex: 12 nTPM
hippocampal formation: 9.9 nTPM
basal ganglia: 9.2 nTPM
hypothalamus: 9.2 nTPM
white matter: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.03
gnomAD missense Z: 1.53
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF304 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

USP28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF304 as an antibody target. Whether an autoantibody or antibody against ZNF304 could matter depends on whether native ZNF304 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF304 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF304 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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