Seroatlas · Human Serome Atlas

ZNF285

Zinc finger protein 285

Also known as: ZN285_HUMAN, ZNF285A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NJ3
Gene: ZNF285
Ensembl: ENSG00000267508
Chromosome: 19
Canonical length: 590 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>Q96NJ3|ZNF285
     1  MIKFQERVTF KDVAVVFTKE ELALLDKAQI NLYQDVMLEN FRNLMLVRDG IKNNILNLQA
    61  KGLSYLSQEV LHCWQIWKQR IRDLTVSQDY IVNLQEECSP HLEDVSLSEE WAGISLQISE
   121  NENYVVNAII KNQDITAWQS LTQVLTPESW RKANIMTEPQ NSQGRYKGIY MEEKLYRRAQ
   181  HDDSLSWTSC DHHESQECKG EDPGRHPSCG KNLGMKSTVE KRNAAHVLPQ PFPCNNCGVA
   241  FADDTDPHVH HSTHLGEKSY KCDQYGKNFS QSQDLIVHCK THSGKTPYEF HEWPMGCKQS
   301  SDLPRYQKVS SGDKPYKCKE CGKGFRRSSS LHNHHRVHTG EMPYKCDECG KGFGFRSLLC
   361  IHQGVHTGKK PYKCEECGKG FDQSSNLLVH QRVHTGEKPY KCSECGKCFS SSSVLQVHWR
   421  FHTGEKPYRC GECGKGFSQC THLHIHQRVH TGEKPYKCNV CGKDFAYSSV LHTHQRVHTG
   481  EKPYKCEVCG KCFSYSSYFH LHQRDHIREK PYKCDECGKG FSRNSDLNVH LRVHTGERPY
   541  KCKACGKGFS RNSYLLAHQR VHIDETQYTH CERGKDLLTH QRLHEQRETL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF285 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 6.4 nTPM
retina: 5.2 nTPM
ovary: 5.1 nTPM
hypothalamus: 4.1 nTPM
basal ganglia: 3.9 nTPM
hippocampal formation: 3.4 nTPM

Single-cell type

bergmann glia: 14 nCPM
oligodendrocyte progenitor cells: 13 nCPM
other brain neurons: 13 nCPM
brain inhibitory neurons: 11 nCPM
brain excitatory neurons: 10 nCPM
oligodendrocytes: 9.5 nCPM

Immune cell

naive B-cell: 4.1 nTPM
naive CD8 T-cell: 2.3 nTPM
naive CD4 T-cell: 2.2 nTPM
basophil: 1.8 nTPM
memory B-cell: 1.7 nTPM
NK-cell: 1.2 nTPM

Brain region

cerebellum: 8.6 nTPM
white matter: 8.5 nTPM
hypothalamus: 7.4 nTPM
amygdala: 6.9 nTPM
basal ganglia: 6.8 nTPM
cerebral cortex: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -1.27
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF285 as an antibody target. Whether an autoantibody or antibody against ZNF285 could matter depends on whether native ZNF285 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF285 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF285 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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