Seroatlas · Human Serome Atlas

ZNF284

Zinc finger protein 284

Also known as: DKFZp781F1775, ZN284_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2VY69
Gene: ZNF284
Ensembl: ENSG00000186026
Chromosome: 19
Canonical length: 593 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>Q2VY69|ZNF284
     1  MTMFKEAVTF KDVAVVFTEE ELGLLDVSQR KLYRDVMLEN FRNLLSVGHQ LSHRDTFHFQ
    61  REEKFWIMET ATQREGNSGG KIQTELESVP ETGPHEEWSC QQIWEQTASE LTRPQDSISS
   121  SQFSTQGDVP SQVDAGLSII HIGETPSEHG KCKKFFSDVS ILDLHQQLHS GKISHTCNEY
   181  RKRFCYSSAL CLHQKVHMGE KRYKCDVCSK AFSQNSQLQT HQRIHTGEKP FKCEQCGKSF
   241  SRRSGMYVHC KLHTGEKPHI CEECGKAFIH NSQLREHQRI HTGEKPFKCY ICGKSFHSRS
   301  NLNRHSMVHM QEKSFRCDTC SNSFGQRSAL NSHCMDHTKE KLYKCEECGR SFTCRQDLCK
   361  HQMDHTGDKP YNCNVCGKGF RWSSCLSRHQ RVHNGETTFK CDGCGKRFYM NSQGHSHQRA
   421  YREEELYKCQ KCGKGYISKF NLDLHQRVHT GERPYNCKEC GKSFRWASGI LRHKRLHTGE
   481  KPFKCEECGK RFTENSKLRF HQRIHTGEKP YKCEECGKGF RWASTHLTHQ RLHSREKLFQ
   541  CEDCGKSSEH SSCLQDQQSD HSGEKTSKCE DCGKRYERRL NLDMILSLFL NDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF284 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

skin: 2.7 nTPM
retina: 2.1 nTPM
spleen: 2 nTPM
cerebellum: 1.9 nTPM
adrenal gland: 1.6 nTPM
thymus: 1.6 nTPM

Single-cell type

choroid plexus epithelial cells: 6.9 nCPM
hepatic stellate cells: 6.5 nCPM
megakaryocytes: 6.2 nCPM
melanocytes: 5.5 nCPM
oligodendrocyte progenitor cells: 5.4 nCPM
other brain neurons: 5 nCPM

Immune cell

NK-cell: 3.7 nTPM
naive CD8 T-cell: 2.5 nTPM
naive CD4 T-cell: 2.4 nTPM
T-reg: 2.2 nTPM
gdT-cell: 2 nTPM
memory CD4 T-cell: 2 nTPM

Brain region

cerebellum: 8.4 nTPM
thalamus: 7.3 nTPM
white matter: 7.3 nTPM
choroid plexus: 6.9 nTPM
cerebral cortex: 6.7 nTPM
basal ganglia: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -0.21
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF284 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF284 as an antibody target. Whether an autoantibody or antibody against ZNF284 could matter depends on whether native ZNF284 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF284 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF284 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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