Seroatlas · Human Serome Atlas

ZNF273

Zinc finger protein 273

Also known as: HZF9, ZN273_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14593
Gene: ZNF273
Ensembl: ENSG00000198039
Chromosome: 7
Canonical length: 569 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q14593|ZNF273
     1  MSSAPRGPPS VAPLPAGIGR STAKTPGLPG SLEMGPLTFR DVAIEFSLEE WQCLDTSQQN
    61  LYRNVMLDNY RNLVFLGIAV SKPDLITCLE QGKEPCNMKR HAMVAKPPVV CSHFAQDLWP
   121  KQGLKDSFQK VILRRYGKYG HENLQLRKGC KSADEHKVHK RGYNGLNQCL TTTQSKIFQC
   181  DKYVKVLHKF SNSNIHKKRQ TGKKPFKCKE CGKSCCILSQ LTQHKKTATR VNFYKCKTCG
   241  KAFNQFSNLT KHKIIHPEVN PYKCEECGKA FNQSLTLTKH KKIHTEEKPY KCEDCGKVFS
   301  VFSVLTKHKI IHTGTKPYNC EECGKGFSIF STLTKHKIIH TGEKPYKCNE CGKAFNWSST
   361  LTKHKRIHTG EKPYKCEECG KAFNQSSTLT RHKIVHTGEK PYKCEECGKA FKRSTTLTKH
   421  KRIYTKEKPY KCEECGKAFS VFSTLTKHKI IHTGAKPYKC EECGSAFRAF STLTEHKRVH
   481  TGEKPYKCNE CGKAFNWSST LTKHKRIHTG EKPYKCEECG KAFNRSSNLT RHKKIHTGEK
   541  PYKPKRCDSA FDNTPNFSRH KRNHMGEKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF273 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 11 nTPM
skin: 5.4 nTPM
basal ganglia: 4.2 nTPM
cerebral cortex: 2.9 nTPM
hippocampal formation: 2.9 nTPM
esophagus: 2.7 nTPM

Single-cell type

ependymal cells: 321 nCPM
choroid plexus epithelial cells: 204 nCPM
respiratory ciliated cells: 135 nCPM
fallopian tube ciliated cells: 82 nCPM
erythrocyte progenitors: 79 nCPM
brain excitatory neurons: 75 nCPM

Immune cell

basophil: 2.3 nTPM
memory B-cell: 0.6 nTPM
MAIT T-cell: 0.5 nTPM
naive CD8 T-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM

Brain region

cerebral cortex: 7.2 nTPM
cerebellum: 7.1 nTPM
midbrain: 6.3 nTPM
basal ganglia: 5.2 nTPM
medulla oblongata: 5.2 nTPM
hippocampal formation: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0.03
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF273 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF273 as an antibody target. Whether an autoantibody or antibody against ZNF273 could matter depends on whether native ZNF273 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF273 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF273 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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