Seroatlas · Human Serome Atlas

ZNF266

Zinc finger protein 266

Also known as: HZF1, ZN266_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14584
Gene: ZNF266
Ensembl: ENSG00000174652
Chromosome: 19
Canonical length: 549 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles,Rods & Rings

OverviewNCBI Gene

This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q14584|ZNF266
     1  MLENYKNLAT VGYQLFKPSL ISWLEQEESR TVQRGDFQAS EWKVQLKTKE LALQQDVLGE
    61  PTSSGIQMIG SHNGGEVSDV KQCGDVSSEH SCLKTHVRTQ NSENTFECYL YGVDFLTLHK
   121  KTSTGEQRSV FSQCGKAFSL NPDVVCQRTC TGEKAFDCSD SGKSFINHSH LQGHLRTHNG
   181  ESLHEWKECG RGFIHSTDLA VRIQTHRSEK PYKCKECGKG FRYSAYLNIH MGTHTGDNPY
   241  ECKECGKAFT RSCQLTQHRK THTGEKPYKC KDCGRAFTVS SCLSQHMKIH VGEKPYECKE
   301  CGIAFTRSSQ LTEHLKTHTA KDPFECKICG KSFRNSSCLS DHFRIHTGIK PYKCKDCGKA
   361  FTQNSDLTKH ARTHSGERPY ECKECGKAFA RSSRLSEHTR THTGEKPFEC VKCGKAFAIS
   421  SNLSGHLRIH TGEKPFECLE CGKAFTHSSS LNNHMRTHSA KKPFTCMECG KAFKFPTCVN
   481  LHMRIHTGEK PYKCKQCGKS FSYSNSFQLH ERTHTGEKPY ECKECGKAFS SSSSFRNHER
   541  RHADERLSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF266 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

epididymis: 50 nTPM
spleen: 40 nTPM
prostate: 28 nTPM
tonsil: 26 nTPM
small intestine: 26 nTPM
thymus: 26 nTPM

Single-cell type

nk-cells: 56 nCPM
lactotrophs: 44 nCPM
sertoli cells: 44 nCPM
innate lymphoid cells: 39 nCPM
somatotrophs: 38 nCPM
renal collecting duct intercalated cells: 35 nCPM

Immune cell

NK-cell: 11 nTPM
gdT-cell: 9.6 nTPM
naive CD8 T-cell: 8.1 nTPM
naive CD4 T-cell: 7.5 nTPM
T-reg: 7.5 nTPM
memory CD8 T-cell: 7.3 nTPM

Brain region

cerebellum: 10 nTPM
choroid plexus: 10 nTPM
white matter: 8.9 nTPM
thalamus: 7.6 nTPM
basal ganglia: 7.5 nTPM
midbrain: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0.02
gnomAD missense Z: -0.42
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF266 as an antibody target. Whether an autoantibody or antibody against ZNF266 could matter depends on whether native ZNF266 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF266 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF266 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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