Seroatlas · Human Serome Atlas

ZNF250

Zinc finger protein 250

Also known as: MGC9718, ZFP647, ZN250_HUMAN, ZNF647

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P15622
Gene: ZNF250
Ensembl: ENSG00000196150
Chromosome: 8
Canonical length: 560 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>P15622|ZNF250
     1  MAAARLLPVP AGPQPLSFQA KLTFEDVAVL LSQDEWDRLC PAQRGLYRNV MMETYGNVVS
    61  LGLPGSKPDI ISQLERGEDP WVLDRKGAKK SQGLWSDYSD NLKYDHTTAC TQQDSLSCPW
   121  ECETKGESQN TDLSPKPLIS EQTVILGKTP LGRIDQENNE TKQSFCLSPN SVDHREVQVL
   181  SQSMPLTPHQ AVPSGERPYM CVECGKCFGR SSHLLQHQRI HTGEKPYVCS VCGKAFSQSS
   241  VLSKHRRIHT GEKPYECNEC GKAFRVSSDL AQHHKIHTGE KPHECLECRK AFTQLSHLIQ
   301  HQRIHTGERP YVCPLCGKAF NHSTVLRSHQ RVHTGEKPHR CNECGKTFSV KRTLLQHQRI
   361  HTGEKPYTCS ECGKAFSDRS VLIQHHNVHT GEKPYECSEC GKTFSHRSTL MNHERIHTEE
   421  KPYACYECGK AFVQHSHLIQ HQRVHTGEKP YVCGECGHAF SARRSLIQHE RIHTGEKPFQ
   481  CTECGKAFSL KATLIVHLRT HTGEKPYECN SCGKAFSQYS VLIQHQRIHT GEKPYECGEC
   541  GRAFNQHGHL IQHQKVHRKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF250 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 9.3 nTPM
skin: 8.5 nTPM
cerebellum: 8.2 nTPM
ovary: 8.2 nTPM
retina: 7.3 nTPM
endometrium: 6.9 nTPM

Single-cell type

neutrophils: 95 nCPM
nk-cells: 45 nCPM
podocytes: 43 nCPM
cardiomyocytes: 40 nCPM
early primary spermatocytes: 38 nCPM
plasma cells: 37 nCPM

Immune cell

T-reg: 12 nTPM
gdT-cell: 11 nTPM
memory B-cell: 10 nTPM
naive B-cell: 9.8 nTPM
naive CD4 T-cell: 8.9 nTPM
MAIT T-cell: 8.1 nTPM

Brain region

cerebellum: 30 nTPM
hypothalamus: 18 nTPM
cerebral cortex: 16 nTPM
midbrain: 16 nTPM
pons: 16 nTPM
white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.28
gnomAD missense Z: 2.34
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF250 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF250 as an antibody target. Whether an autoantibody or antibody against ZNF250 could matter depends on whether native ZNF250 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF250 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF250 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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