Seroatlas · Human Serome Atlas

ZNF25

Zinc finger protein 25

Also known as: FLJ31890, KOX19, Zfp9, ZNF25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17030
Gene
ZNF25
Ensembl
ENSG00000175395
Chromosome
10
Canonical length
456 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>P17030|ZNF25
     1  MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH VNKPNAVFKL
    61  KQGKEPWILE VEFPHRGFPE DLWSIHDLEA RYQESQAGNS RNGELTKHQK THTTEKACEC
   121  KECGKFFCQK SALIVHQHTH SKGKSYDCDK CGKSFSKNED LIRHQKIHTR DKTYECKECK
   181  KIFYHLSSLS RHLRTHAGEK PYECNQCEKS FYQKPHLTEH QKTHTGEKPF ECTECGKFFY
   241  VKAYLMVHQK THTGEKPYEC KECGKAFSQK SHLTVHQRMH TGEKPYKCKE CGKFFSRNSH
   301  LKTHQRSHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT FYYKSDLTKH
   361  QRKHTGEKPY ECTECGKSFA VNSVLRLHQR THTGEKPYAC KECGKSFSQK SHFIIHQRKH
   421  TGEKPYECQE CGETFIQKSQ LTAHQKTHTK KRNAEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 26 nTPM
  • cerebral cortex: 24 nTPM
  • skeletal muscle: 21 nTPM
  • tongue: 20 nTPM
  • hypothalamus: 19 nTPM
  • blood vessel: 16 nTPM

Single-cell type

  • lactotrophs: 69 nCPM
  • other brain neurons: 59 nCPM
  • late spermatids: 58 nCPM
  • brain inhibitory neurons: 55 nCPM
  • brain excitatory neurons: 55 nCPM
  • early spermatids: 52 nCPM

Immune cell

  • non-classical monocyte: 5.3 nTPM
  • eosinophil: 3.4 nTPM
  • intermediate monocyte: 2.5 nTPM
  • myeloid DC: 1.9 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • MAIT T-cell: 1.7 nTPM

Brain region

  • cerebral cortex: 38 nTPM
  • hypothalamus: 32 nTPM
  • cerebellum: 25 nTPM
  • white matter: 24 nTPM
  • pons: 24 nTPM
  • basal ganglia: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
-0.15
DepMap mean gene effect
0.2
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF25 as an antibody target. Whether an autoantibody or antibody against ZNF25 could matter depends on whether native ZNF25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF25. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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