Seroatlas · Human Serome Atlas

ZNF233

Zinc finger protein 233

Also known as: FLJ38032, ZN233_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NK53
Gene: ZNF233
Ensembl: ENSG00000159915
Chromosome: 19
Canonical length: 670 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>A6NK53|ZNF233
     1  MTKFQEMVTF KDVAVVFTRE ELGLLDLAQR KLYQDVMLEN FRNLLSVGYQ PFKLDVILQL
    61  GKEDKLRMME TEIQGDGCSG HKNQNEIDTL QEVRLRFLSY EDLICWQIWE QFTSKLTSNQ
   121  DLIINLQGKR SKLLKQGDSP CQVWTGESSQ VSEDENYVIK LQGESSNSIK NQELPLRTTW
   181  DFWRKMYLRE PQNYQSRCQQ IDVKNKLCKC DHCVRQRIAH QHDDHGVHKR EKAFSHNNCG
   241  KDCVKESSQH SIIQSGEQTS DENGKGLSVG SNLELHQQLH LRDKPHVNVE YGKGIGYSSG
   301  LPRHQCFHIG EKCYRNGDSG EGFSQGSHLQ PHQRVSTGEN LYRCQVYARS SNQNSCLPSH
   361  ELTHPGEKLC TCGRCGKGFH HSLDFDIHCV DSAGERACKC DVYDKGFSQT SQLQAHQRGH
   421  SRDKTYKWEV SDRIFNRNSG LHQRVHTGEK PYKCEVCDKG FSKASNLQAH QRIHTGEKPY
   481  KCDVCDKNFS RNSHLQAHQR VHTGEKPYKC DTCGKDFSQI SHLQAHQRVH KGEKPYKCET
   541  CGKGFSQSSH LQDHQQVHTG ENPYKCDVCG KGFSWSSHLQ AHQRVHTGEK PYKCEECRKG
   601  FIWNSYLHVH QRIHTGEKPY KCGMCGKSFS QTSHLQAHQR VHTGEKPYKC FVCGKGFSKS
   661  SLSSDSSESP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF233 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
retina: 4.5 nTPM
cerebral cortex: 3 nTPM
heart muscle: 2.9 nTPM
prostate: 2.6 nTPM
thyroid gland: 1.8 nTPM

Single-cell type

late primary spermatocytes: 97 nCPM
cardiomyocytes: 57 nCPM
epicardial cells: 46 nCPM
early spermatids: 27 nCPM
other brain neurons: 13 nCPM
podocytes: 13 nCPM

Immune cell

basophil: 1.4 nTPM
naive B-cell: 1.3 nTPM
plasmacytoid DC: 1.3 nTPM
NK-cell: 1.1 nTPM
memory B-cell: 0.8 nTPM
naive CD8 T-cell: 0.7 nTPM

Brain region

cerebellum: 36 nTPM
cerebral cortex: 36 nTPM
basal ganglia: 33 nTPM
pons: 33 nTPM
white matter: 33 nTPM
hypothalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF233 as an antibody target. Whether an autoantibody or antibody against ZNF233 could matter depends on whether native ZNF233 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF233 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF233 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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