Seroatlas · Human Serome Atlas

ZNF211

Zinc finger protein 211

Also known as: CH2H2-25, ZN211_HUMAN, ZNF-25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13398
Gene: ZNF211
Ensembl: ENSG00000121417
Chromosome: 19
Canonical length: 564 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Mitochondria,Rods & Rings

OverviewNCBI Gene

This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

564 residues, UniProt reviewed canonical sequence.

>Q13398|ZNF211
     1  MLGFPPGRPQ LPVQLRPQTR MATALRDPAS GSVTFEDVAV YFSWEEWDLL DEAQKHLYFD
    61  VMLENFALTS SLGCWCGVEH EETPSEQRIS GERVPQFRTS KEGSSSQNAD SCEICCLVLR
   121  DILHLAEHQG TNCGQKLHTC GKQFYISANL QQHQRQHITE APFRSYVDTA SFTQSCIVHV
   181  SEKPFTCREI RKDFLANMRF LHQDATQTGE KPNNSNKCAV AFYSGKSHHN WGKCSKAFSH
   241  IDTLVQDQRI LTREGLFECS KCGKACTRRC NLIQHQKVHS EERPYECNEC GKFFTYYSSF
   301  IIHQRVHTGE RPYACPECGK SFSQIYSLNS HRKVHTGERP YECGECGKSF SQRSNLMQHR
   361  RVHTGERPYE CSECGKSFSQ NFSLIYHQRV HTGERPHECN ECGKSFSRSS SLIHHRRLHT
   421  GERPYECSKC GKSFKQSSSF SSHRKVHTGE RPYVCGECGK SFSHSSNLKN HQRVHTGERP
   481  VECSECSKSF SCKSNLIKHL RVHTGERPYE CSECGKSFSQ SSSLIQHRRV HTGKRPYQCS
   541  QCGKSFGCKS VLIQHQRVHI GEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF211 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 29 nTPM
bone marrow: 22 nTPM
cerebellum: 19 nTPM
spleen: 17 nTPM
retina: 17 nTPM
pituitary gland: 17 nTPM

Single-cell type

syncytiotrophoblasts: 31 nCPM
bergmann glia: 30 nCPM
retinal pigment epithelial cells: 26 nCPM
astrocytes: 23 nCPM
oligodendrocyte progenitor cells: 22 nCPM
cardiomyocytes: 21 nCPM

Immune cell

eosinophil: 12 nTPM
MAIT T-cell: 12 nTPM
naive CD4 T-cell: 12 nTPM
T-reg: 12 nTPM
memory CD8 T-cell: 11 nTPM
naive B-cell: 11 nTPM

Brain region

choroid plexus: 28 nTPM
cerebellum: 19 nTPM
amygdala: 17 nTPM
white matter: 17 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF211 as an antibody target. Whether an autoantibody or antibody against ZNF211 could matter depends on whether native ZNF211 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF211 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF211 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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