Seroatlas · Human Serome Atlas

ZNF207

BUB3-interacting and GLEBS motif-containing protein ZNF207

Also known as: BuGZ, ZN207_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43670
Gene
ZNF207
Ensembl
ENSG00000010244
Chromosome
17
Canonical length
478 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables microtubule binding activity. Involved in mitotic spindle assembly checkpoint signaling; nuclear chromosome segregation; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>O43670|ZNF207
     1  MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL AIHCMQVHKE
    61  TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK TQESQKKKQQ DDSDEYDDDD
   121  SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG
   181  MPPGMMPMGG MMPPGPGIPP LMPGMPPGMP PPVPRPGIPP MTQAQAVSAP GILNRPPAPT
   241  ATVPAPQPPV TKPLFPSAGQ MGTPVTSSST ASSNSESLSA SSKALFPSTA QAQAAVQGPV
   301  GTDFKPLNST PATTTEPPKP TFPAYTQSTA STTSTTNSTA AKPAASITSK PATLTTTSAT
   361  SKLIHPDEDI SLEERRAQLP KYQRNLPRPG QAPIGNPPVG PIGGMMPPQP GIPQQQGMRP
   421  PMPPHGQYGG HHQGMPGYLP GAMPPYGQGP PMVPPYQGGP PRPPMGMRPP VMSQGGRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF207 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
226 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 226 nTPM
  • tonsil: 120 nTPM
  • esophagus: 105 nTPM
  • thymus: 97 nTPM
  • lymph node: 94 nTPM
  • urinary bladder: 87 nTPM

Single-cell type

  • esophageal apical cells: 440 nCPM
  • neutrophil progenitors: 386 nCPM
  • myonuclei: 301 nCPM
  • adrenal cortex cells: 285 nCPM
  • neutrophils: 262 nCPM
  • extravillous trophoblasts: 249 nCPM

Immune cell

  • basophil: 110 nTPM
  • myeloid DC: 100 nTPM
  • non-classical monocyte: 93 nTPM
  • total PBMC: 91 nTPM
  • T-reg: 87 nTPM
  • intermediate monocyte: 85 nTPM

Brain region

  • cerebellum: 96 nTPM
  • white matter: 88 nTPM
  • choroid plexus: 85 nTPM
  • cerebral cortex: 85 nTPM
  • spinal cord: 77 nTPM
  • medulla oblongata: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.1
gnomAD missense Z
2.51
DepMap mean gene effect
-1.21
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF207 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF207 as an antibody target. Whether an autoantibody or antibody against ZNF207 could matter depends on whether native ZNF207 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF207 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF207 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF207. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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