Seroatlas · Human Serome Atlas

ZNF177

Zinc finger protein 177

Also known as: ZN177_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13360
Gene: ZNF177
Ensembl: ENSG00000188629
Chromosome: 19
Canonical length: 481 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in blood microparticle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q13360|ZNF177
     1  MAAGWLTTWS QNSVTFQEVA VDFSQEEWAL LDPAQKNLYK DVMLENFRNL ASVGYQLCRH
    61  SLISKVDQEQ LKTDERGILQ GDCADWETQL KPKDTIAMQN IPGGKTSNGI NTAENQPGEH
   121  SLECNHCGKF RKNTRFICTR YCKGEKCYKY IKYSKVFNHP STLRSHVSIH IGEKTLEFTD
   181  CRKAFNQESS LRKHLRTPTG QKFQEYEQCD MSFSLHSSCS VREQIPTGEK GDECSDYGKI
   241  SPLSVHTKTG SVEEGLECNE HEKTFTDPLS LQNCVRTHSG EMPYECSDCG KAFIFQSSLK
   301  KHMRSHTGEK PYECDHCGKS FSQSSHLNVH KRTHTGEKPY DCKECGKAFT VPSSLQKHVR
   361  THTGEKPYEC SDCGKAFIDQ SSLKKHTRSH TGEKPYECNQ CGKSFSTGSY LIVHKRTHTG
   421  EKTYECKECG KAFRNSSCLR VHVRTHTGEK PYKCIQCEKA FSTSTNLIMH KRIHNGQKLH
   481  E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF177 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 11 nTPM
testis: 9.8 nTPM
retina: 9.6 nTPM
ovary: 8.2 nTPM
epididymis: 7.9 nTPM
kidney: 7.8 nTPM

Single-cell type

astrocytes: 19 nCPM
bergmann glia: 18 nCPM
ependymal cells: 17 nCPM
oligodendrocyte progenitor cells: 15 nCPM
other brain neurons: 14 nCPM
oligodendrocytes: 13 nCPM

Immune cell

NK-cell: 0.8 nTPM
basophil: 0.6 nTPM
eosinophil: 0.4 nTPM
gdT-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
myeloid DC: 0.4 nTPM

Brain region

cerebellum: 14 nTPM
white matter: 11 nTPM
hippocampal formation: 10 nTPM
basal ganglia: 10 nTPM
cerebral cortex: 10 nTPM
medulla oblongata: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.71
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF177 as an antibody target. Whether an autoantibody or antibody against ZNF177 could matter depends on whether native ZNF177 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF177 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF177 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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