Seroatlas · Human Serome Atlas

ZNF169

Zinc finger protein 169

Also known as: MGC51961, ZN169_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14929
Gene
ZNF169
Ensembl
ENSG00000175787
Chromosome
9
Canonical length
603 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

603 residues, UniProt reviewed canonical sequence.

>Q14929|ZNF169
     1  MSPGLLTTRK EALMAFRDVA VAFTQKEWKL LSSAQRTLYR EVMLENYSHL VSLGIAFSKP
    61  KLIEQLEQGD EPWREENEHL LDLCPEPRTE FQPSFPHLVA FSSSQLLRQY ALSGHPTQIF
   121  PSSSAGGDFQ LEAPRCSSEK GESGETEGPD SSLRKRPSRI SRTFFSPHQG DPVEWVEGNR
   181  EGGTDLRLAQ RMSLGGSDTM LKGADTSESG AVIRGNYRLG LSKKSSLFSH QKHHVCPECG
   241  RGFCQRSDLI KHQRTHTGEK PYLCPECGRR FSQKASLSIH QRKHSGEKPY VCRECGRHFR
   301  YTSSLTNHKR IHSGERPFVC QECGRGFRQK IALLLHQRTH LEEKPFVCPE CGRGFCQKAS
   361  LLQHQSSHTG ERPFLCLECG RSFRQQSLLL SHQVTHSGEK PYVCAECGHS FRQKVTLIRH
   421  QRTHTGEKPY LCPQCGRGFS QKVTLIGHQR THTGEKPYLC PDCGRGFGQK VTLIRHQRTH
   481  TGEKPYLCPK CGRAFGFKSL LTRHQRTHSE EELYVDRVCG QGLGQKSHLI SDQRTHSGEK
   541  PCICDECGRG FGFKSALIRH QRTHSGEKPY VCRECGRGFS QKSHLHRHRR TKSGHQLLPQ
   601  EVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF169 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
5.9 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 5.9 nTPM
  • cerebellum: 5.8 nTPM
  • lymph node: 5.5 nTPM
  • small intestine: 5.5 nTPM
  • ovary: 5.3 nTPM
  • cerebral cortex: 5.2 nTPM

Single-cell type

  • goblet cells: 35 nCPM
  • choroid plexus epithelial cells: 34 nCPM
  • adrenal cortex cells: 34 nCPM
  • microglia: 33 nCPM
  • fibro-adipogenic progenitors: 29 nCPM
  • distal convoluted tubule cells: 29 nCPM

Immune cell

  • naive CD8 T-cell: 4.1 nTPM
  • naive B-cell: 4 nTPM
  • intermediate monocyte: 3.4 nTPM
  • NK-cell: 3.2 nTPM
  • eosinophil: 3.1 nTPM
  • MAIT T-cell: 3.1 nTPM

Brain region

  • white matter: 17 nTPM
  • cerebral cortex: 15 nTPM
  • pons: 14 nTPM
  • cerebellum: 14 nTPM
  • choroid plexus: 14 nTPM
  • hippocampal formation: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0
gnomAD missense Z
0.22
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF169 as an antibody target. Whether an autoantibody or antibody against ZNF169 could matter depends on whether native ZNF169 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF169 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF169 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF169. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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