Seroatlas · Human Serome Atlas

ZNF155

Zinc finger protein 155

Also known as: pHZ-96, ZN155_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12901
Gene: ZNF155
Ensembl: ENSG00000204920
Chromosome: 19
Canonical length: 538 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q12901|ZNF155
     1  MTTFKEAVTF KDVAVVFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGHQ PFHQDTCHFL
    61  REEKFWMMGT ATQREGNSGG KIQTELESVP EAGAHEEWSC QQIWEQIAKD LTRSQDSIIN
   121  NSQFFENGDV PSQVEAGLPT IHTGQKPSQG GKCKQSISDV PIFDLPQQLY SEEKSYTCDE
   181  CGKSICYISA LHVHQRVHVG EKLFMCDVCG KEFSQSSHLQ THQRVHTGEK PFKCEQCGKG
   241  FSRRSALNVH RKLHTGEKPY ICEACGKAFI HDSQLKEHKR IHTGEKPFKC DICGKTFYFR
   301  SRLKSHSMVH TGEKPFRCDT CDKSFHQRSA LNRHCMVHTG EKPYRCEQCG KGFIGRLDFY
   361  KHQVVHTGEK PYNCKECGKS FRWSSCLLNH QRVHSGEKSF KCEECGKGFY TNSQLSSHQR
   421  SHSGEKPYKC EECGKGYVTK FNLDLHQRVH TGERPYNCKE CGKNFSRASS ILNHKRLHCQ
   481  KKPFKCEDCG KRLVHRTYRK DQPRDYSGEN PSKCEDCGRR YKRRLNLDIL LSLFLNDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF155 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

retina: 7.9 nTPM
parathyroid gland: 7.7 nTPM
thyroid gland: 7.3 nTPM
cerebellum: 6.4 nTPM
thymus: 6.1 nTPM
liver: 6 nTPM

Single-cell type

bergmann glia: 42 nCPM
thyrotrophs: 34 nCPM
choroid plexus epithelial cells: 34 nCPM
astrocytes: 32 nCPM
hematopoietic stem cells: 31 nCPM
oligodendrocytes: 30 nCPM

Immune cell

eosinophil: 9.9 nTPM
basophil: 8.1 nTPM
memory CD8 T-cell: 7 nTPM
gdT-cell: 6.5 nTPM
MAIT T-cell: 6.3 nTPM
naive CD4 T-cell: 5.5 nTPM

Brain region

cerebellum: 16 nTPM
white matter: 12 nTPM
hypothalamus: 11 nTPM
basal ganglia: 11 nTPM
choroid plexus: 10 nTPM
thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.52
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF155 as an antibody target. Whether an autoantibody or antibody against ZNF155 could matter depends on whether native ZNF155 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF155 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF155 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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