Seroatlas · Human Serome Atlas

ZMIZ2

Zinc finger MIZ domain-containing protein 2

Also known as: DKFZp761I2123, hZIMP7, KIAA1886, NET27, ZIMP7, ZMIZ2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NF64
Gene: ZMIZ2
Ensembl: ENSG00000122515
Chromosome: 7
Canonical length: 920 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]

Canonical amino-acid sequenceUniProt

920 residues, UniProt reviewed canonical sequence.

>Q8NF64|ZMIZ2
     1  MNSMNPMKPA LPPAPHGDGS FAYESVPWQQ SATQPAGSLS VVTTVWGVGN ATQSQVLGNP
    61  MGPAGSPSGS SMMPGVAGGS SALTSPQCLG QQAFAEGGAN KGYVQQGVYS RGGYPGAPGF
   121  TTGYAGGPGG LGLPSHAARP STDFTQAAAA AAVAAAAATA TATATATVAA LQEKQSQELS
   181  QYGAMGAGQS FNSQFLQHGG PRGPSVPAGM NPTGIGGVMG PSGLSPLAMN PTRAAGMTPL
   241  YAGQRLPQHG YPGPPQAQPL PRQGVKRTYS EVYPGQQYLQ GGQYAPSTAQ FAPSPGQPPA
   301  PSPSYPGHRL PLQQGMTQSL SVPGPTGLHY KPTEQFNGQG ASFNGGSVSY SQPGLSGPTR
   361  SIPGYPSSPL PGNPTPPMTP SSSVPYMSPN QEVKSPFLPD LKPNLNSLHS SPSGSGPCDE
   421  LRLTFPVRDG VVLEPFRLQH NLAVSNHVFQ LRDSVYKTLI MRPDLELQFK CYHHEDRQMN
   481  TNWPASVQVS VNATPLTIER GDNKTSHKPL YLKHVCQPGR NTIQITVTAC CCSHLFVLQL
   541  VHRPSVRSVL QGLLKKRLLP AEHCITKIKR NFSSGTIPGT PGPNGEDGVE QTAIKVSLKC
   601  PITFRRIQLP ARGHDCRHIQ CFDLESYLQL NCERGTWRCP VCNKTALLEG LEVDQYMLGI
   661  LIYIQNSDYE EITIDPTCSW KPVPVKPDMH IKEEPDGPAL KRCRTVSPAH VLMPSVMEMI
   721  AALGPGAAPF APLQPPSVPA PSDYPGQGSS FLGPGTFPES FPPTTPSTPT LAEFTPGPPP
   781  ISYQSDIPSS LLTSEKSTAC LPSQMAPAGH LDPTHNPGTP GLHTSNLGAP PGPQLHHSNP
   841  PPASRQSLGQ ASLGPTGELA FSPATGVMGP PSMSGAGEAP EPALDLLPEL TNPDELLSYL
   901  GPPDLPTNNN DDLLSLFENN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMIZ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 60 nTPM
amygdala: 42 nTPM
hippocampal formation: 39 nTPM
thyroid gland: 38 nTPM
pituitary gland: 35 nTPM
cerebellum: 34 nTPM

Single-cell type

late spermatids: 156 nCPM
adrenal cortex cells: 73 nCPM
cdc: 72 nCPM
proximal tubule cells: 69 nCPM
tuft cells: 58 nCPM
somatotrophs: 51 nCPM

Immune cell

naive B-cell: 1.8 nTPM
plasmacytoid DC: 1.5 nTPM
NK-cell: 1.1 nTPM
memory B-cell: 1 nTPM
gdT-cell: 0.8 nTPM
intermediate monocyte: 0.8 nTPM

Brain region

cerebral cortex: 104 nTPM
amygdala: 97 nTPM
hippocampal formation: 93 nTPM
white matter: 83 nTPM
basal ganglia: 79 nTPM
thalamus: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 1.92
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMIZ2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMIZ2 as an antibody target. Whether an autoantibody or antibody against ZMIZ2 could matter depends on whether native ZMIZ2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMIZ2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMIZ2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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