Seroatlas · Human Serome Atlas

ZMAT1

Zinc finger matrin-type protein 1

Also known as: KIAA1789, ZMAT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5H9K5
Gene
ZMAT1
Ensembl
ENSG00000166432
Chromosome
X
Canonical length
638 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein containing Cys2-His2 (C2H2)-type zinc fingers, which are similar to those found in the nuclear matrix protein matrin 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>Q5H9K5|ZMAT1
     1  MESCSVTRLE CSGAISAHCS LHLPGSSDSP ASASQIAGTT DAIWNEQEKA ELFTDKFCQV
    61  CGVMLQFESQ RISHYEGEKH AQNVSFYFQM HGEQNEVPGK KMKMHVENFQ VHRYEGVDKN
   121  KFCDLCNMMF SSPLIAQSHY VGKVHAKKLK QLMEEHDQAS PSGFQPEMAF SMRTYVCHIC
   181  SIAFTSLDMF RSHMQGSEHQ IKESIVINLV KNSRKTQDSY QNECADYINV QKARGLEAKT
   241  CFRKMEESSL ETRRYREVVD SRPRHRMFEQ RLPFETFRTY AAPYNISQAM EKQLPHSKKT
   301  YDSFQDELED YIKVQKARGL DPKTCFRKMR ENSVDTHGYR EMVDSGPRSR MCEQRFSHEA
   361  SQTYQRPYHI SPVESQLPQW LPTHSKRTYD SFQDELEDYI KVQKARGLEP KTCFRKIGDS
   421  SVETHRNREM VDVRPRHRML EQKLPCETFQ TYSGPYSISQ VVENQLPHCL PAHDSKQRLD
   481  SISYCQLTRD CFPEKPVPLS LNQQENNSGS YSVESEVYKH LSSENNTADH QAGHKRKHQK
   541  RKRHLEEGKE RPEKEQSKHK RKKSYEDTDL DKDKSIRQRK REEDRVKVSS GKLKHRKKKK
   601  SHDVPSEKEE RKHRKEKKKS VEERTEEEML WDESILGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 35 nTPM
  • thyroid gland: 24 nTPM
  • epididymis: 20 nTPM
  • spinal cord: 16 nTPM
  • kidney: 15 nTPM
  • basal ganglia: 15 nTPM

Single-cell type

  • pituicytes/fscs: 326 nCPM
  • somatotrophs: 264 nCPM
  • ependymal cells: 245 nCPM
  • thyrotrophs: 242 nCPM
  • pituitary stem cells: 222 nCPM
  • lactotrophs: 211 nCPM

Immune cell

  • naive B-cell: 0.8 nTPM
  • plasmacytoid DC: 0.8 nTPM
  • basophil: 0.7 nTPM
  • eosinophil: 0.5 nTPM
  • memory B-cell: 0.5 nTPM
  • MAIT T-cell: 0.4 nTPM

Brain region

  • white matter: 7.8 nTPM
  • medulla oblongata: 7 nTPM
  • basal ganglia: 6.8 nTPM
  • spinal cord: 5.9 nTPM
  • amygdala: 5.7 nTPM
  • midbrain: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMAT1 as an antibody target. Whether an autoantibody or antibody against ZMAT1 could matter depends on whether native ZMAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZMAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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