Seroatlas · Human Serome Atlas

ZIK1

Zinc finger protein interacting with ribonucleoprotein K

Also known as: ZIK1_HUMAN, ZNF762

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3SY52
Gene
ZIK1
Ensembl
ENSG00000171649
Chromosome
19
Canonical length
487 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Intermediate filaments

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q3SY52|ZIK1
     1  MAAAALRAPT QVTVSPETHM DLTKGCVTFE DIAIYFSQDE WGLLDEAQRL LYLEVMLENF
    61  ALVASLGCGH GTEDEETPSD QNVSVGVSQS KAGSSTQKTQ SCEMCVPVLK DILHLADLPG
   121  QKPYLVGECT NHHQHQKHHS AKKSLKRDMD RASYVKCCLF CMSLKPFRKW EVGKDLPAML
   181  RLLRSLVFPG GKKPGTITEC GEDIRSQKSH YKSGECGKAS RHKHTPVYHP RVYTGKKLYE
   241  CSKCGKAFRG KYSLVQHQRV HTGERPWECN ECGKFFSQTS HLNDHRRIHT GERPYECSEC
   301  GKLFRQNSSL VDHQKIHTGA RPYECSQCGK SFSQKATLVK HQRVHTGERP YKCGECGNSF
   361  SQSAILNQHR RIHTGAKPYE CGQCGKSFSQ KATLIKHQRV HTGERPYKCG DCGKSFSQSS
   421  ILIQHRRIHT GARPYECGQC GKSFSQKSGL IQHQVVHTGE RPYECNKCGN SFSQCSSLIH
   481  HQKCHNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZIK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
6.7 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 6.7 nTPM
  • retina: 6.4 nTPM
  • parathyroid gland: 6.3 nTPM
  • tonsil: 6 nTPM
  • lymph node: 5.5 nTPM
  • cerebellum: 5.4 nTPM

Single-cell type

  • cardiomyocytes: 20 nCPM
  • erythrocyte progenitors: 8.7 nCPM
  • undifferentiated spermatogonia: 8 nCPM
  • epicardial cells: 6.8 nCPM
  • rod photoreceptor cells: 6.8 nCPM
  • esophageal apical cells: 6.2 nCPM

Immune cell

  • naive B-cell: 9.4 nTPM
  • eosinophil: 8.2 nTPM
  • memory B-cell: 6.9 nTPM
  • naive CD4 T-cell: 6.5 nTPM
  • T-reg: 4.4 nTPM
  • NK-cell: 4.1 nTPM

Brain region

  • cerebellum: 14 nTPM
  • hypothalamus: 7.6 nTPM
  • basal ganglia: 7.4 nTPM
  • white matter: 6.9 nTPM
  • choroid plexus: 6.6 nTPM
  • cerebral cortex: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.92
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZIK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZIK1 as an antibody target. Whether an autoantibody or antibody against ZIK1 could matter depends on whether native ZIK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZIK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZIK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZIK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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