Seroatlas · Human Serome Atlas

ZFX

Zinc finger X-chromosomal protein

Also known as: ZFX_HUMAN, ZNF926

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17010
Gene: ZFX
Ensembl: ENSG00000005889
Chromosome: X
Canonical length: 805 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>P17010|ZFX
     1  MDEDGLELQQ EPNSFFDATG ADGTHMDGDQ IVVEVQETVF VSDVVDSDIT VHNFVPDDPD
    61  SVVIQDVIED VVIEDVQCPD IMEEADVSET VIIPEQVLDS DVTEEVSLAH CTVPDDVLAS
   121  DITSASMSMP EHVLTGDSIH VSDVGHVGHV GHVEHVVHDS VVEAEIVTDP LTTDVVSEEV
   181  LVADCASEAV IDANGIPVDQ QDDDKGNCED YLMISLDDAG KIEHDGSSGM TMDTESEIDP
   241  CKVDGTCPEV IKVYIFKADP GEDDLGGTVD IVESEPENDH GVELLDQNSS IRVPREKMVY
   301  MTVNDSQPED EDLNVAEIAD EVYMEVIVGE EDAAAAAAAA AVHEQQMDDN EIKTFMPIAW
   361  AAAYGNNSDG IENRNGTASA LLHIDESAGL GRLAKQKPKK RRRPDSRQYQ TAIIIGPDGH
   421  PLTVYPCMIC GKKFKSRGFL KRHMKNHPEH LAKKKYRCTD CDYTTNKKIS LHNHLESHKL
   481  TSKAEKAIEC DECGKHFSHA GALFTHKMVH KEKGANKMHK CKFCEYETAE QGLLNRHLLA
   541  VHSKNFPHIC VECGKGFRHP SELKKHMRIH TGEKPYQCQY CEYRSADSSN LKTHVKTKHS
   601  KEMPFKCDIC LLTFSDTKEV QQHALIHQES KTHQCLHCDH KSSNSSDLKR HIISVHTKDY
   661  PHKCDMCDKG FHRPSELKKH VAAHKGKKMH QCRHCDFKIA DPFVLSRHIL SVHTKDLPFR
   721  CKRCRKGFRQ QSELKKHMKT HSGRKVYQCE YCEYSTTDAS GFKRHVISIH TKDYPHRCEY
   781  CKKGFRRPSE KNQHIMRHHK EVGLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 28 nTPM
thymus: 16 nTPM
endometrium: 15 nTPM
parathyroid gland: 15 nTPM
skeletal muscle: 14 nTPM
prostate: 14 nTPM

Single-cell type

gonadotrophs: 284 nCPM
neutrophils: 233 nCPM
monocytes: 173 nCPM
myonuclei: 159 nCPM
neutrophil progenitors: 144 nCPM
cytotrophoblasts: 132 nCPM

Immune cell

neutrophil: 12 nTPM
eosinophil: 10 nTPM
basophil: 9.7 nTPM
naive B-cell: 9.5 nTPM
intermediate monocyte: 7.6 nTPM
MAIT T-cell: 7.2 nTPM

Brain region

cerebellum: 68 nTPM
white matter: 54 nTPM
midbrain: 53 nTPM
hypothalamus: 52 nTPM
basal ganglia: 51 nTPM
thalamus: 51 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFX.

Disease | AllUniProt

Conditions ZFX is implicated in, by any mechanism.

Intellectual developmental disorder, X-linked, syndromic 37 (MRXS37) MIM:301118

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 248 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder, X-linked, syndromic 37

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 3.15
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFX as an antibody target. Whether an autoantibody or antibody against ZFX could matter depends on whether native ZFX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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