Seroatlas · Human Serome Atlas

ZFTRAF1

Zinc finger TRAF-type-containing protein 1

Also known as: ZTRF1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DTL6
Gene: ZFTRAF1
Canonical length: 404 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ZFTRAF1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>P0DTL6|ZFTRAF1
     1  MSGAEEAGGG GPAAGPAGSV PAGVGVGVGA GPGAAAGQAA AAALGEAAGP GLPDEAGLAG
    61  ARQLQLQEAA GDPDAPPKKR LRAAEAAEAA AAAAAAGSGK LEERLYSVLC CTVCLDLPKA
   121  SVYQCTNGHL MCAGCFIHLL ADARLKEEQA TCPNCRCEIS KSLCCRNLAV EKAVSELPSE
   181  CGFCLRQFPR SLLERHQKEE CQDRVTQCKY KRIGCPWHGP FHELTVHEAA CAHPTKTGSE
   241  LMEILDGMDQ SHRKEMQLYN SIFSLLSFEK IGYTEVQFRP YRTDDFITRL YYETPRFTVL
   301  NQTWVLKARV NDSERNPNLS CKRTLSFQLL LKSKVTAPLE CSFLLLKGPY DDVRISPVIY
   361  HFVFTNESNE TDYVPLPIID SVECNKLLAA KNINLRLFLF QIQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFTRAF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 9.2 nTPM
testis: 9.1 nTPM
epididymis: 3.3 nTPM
cerebral cortex: 2.5 nTPM
basal ganglia: 2.4 nTPM
adipose tissue: 2.3 nTPM

Single-cell type

brain excitatory neurons: 66 nCPM
other brain neurons: 63 nCPM
astrocytes: 60 nCPM
bergmann glia: 60 nCPM
brain inhibitory neurons: 59 nCPM
ependymal cells: 51 nCPM

Immune cell

neutrophil: 0.7 nTPM
eosinophil: 0.3 nTPM
total PBMC: 0.2 nTPM
basophil: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

pons: 11 nTPM
medulla oblongata: 11 nTPM
midbrain: 11 nTPM
cerebral cortex: 10 nTPM
spinal cord: 9.9 nTPM
thalamus: 9.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFTRAF1.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 13 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with hypotonia and gross motor and speech delay

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, TRAF-type
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type
E3 ubiquitin-protein ligase Sina-like, RING finger
E3 ubiquitin-protein ligase sina/sinah, RING finger
Zinc finger TRAF-type-containing protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFTRAF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LGALS3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFTRAF1 as an antibody target. Whether an autoantibody or antibody against ZFTRAF1 could matter depends on whether native ZFTRAF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFTRAF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFTRAF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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