Seroatlas · Human Serome Atlas

ZFP28

Zinc finger protein 28 homolog

Also known as: KIAA1431, mkr5, ZFP28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHY6
Gene: ZFP28
Ensembl: ENSG00000196867
Chromosome: 19
Canonical length: 868 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

868 residues, UniProt reviewed canonical sequence.

>Q8NHY6|ZFP28
     1  MRGAASASVR EPTPLPGRGA PRTKPRAGRG PTVGTPATLA LPARGRPRSR NGLASKGQRG
    61  AAPTGPGHRA LPSRDTALPQ ERNKKLEAVG TGIEPKAMSQ GLVTFGDVAV DFSQEEWEWL
   121  NPIQRNLYRK VMLENYRNLA SLGLCVSKPD VISSLEQGKE PWTVKRKMTR AWCPDLKAVW
   181  KIKELPLKKD FCEGKLSQAV ITERLTSYNL EYSLLGEHWD YDALFETQPG LVTIKNLAVD
   241  FRQQLHPAQK NFCKNGIWEN NSDLGSAGHC VAKPDLVSLL EQEKEPWMVK RELTGSLFSG
   301  QRSVHETQEL FPKQDSYAEG VTDRTSNTKL DCSSFRENWD SDYVFGRKLA VGQETQFRQE
   361  PITHNKTLSK ERERTYNKSG RWFYLDDSEE KVHNRDSIKN FQKSSVVIKQ TGIYAGKKLF
   421  KCNECKKTFT QSSSLTVHQR IHTGEKPYKC NECGKAFSDG SSFARHQRCH TGKKPYECIE
   481  CGKAFIQNTS LIRHWRYYHT GEKPFDCIDC GKAFSDHIGL NQHRRIHTGE KPYKCDVCHK
   541  SFRYGSSLTV HQRIHTGEKP YECDVCRKAF SHHASLTQHQ RVHSGEKPFK CKECGKAFRQ
   601  NIHLASHLRI HTGEKPFECA ECGKSFSISS QLATHQRIHT GEKPYECKVC SKAFTQKAHL
   661  AQHQKTHTGE KPYECKECGK AFSQTTHLIQ HQRVHTGEKP YKCMECGKAF GDNSSCTQHQ
   721  RLHTGQRPYE CIECGKAFKT KSSLICHRRS HTGEKPYECS VCGKAFSHRQ SLSVHQRIHS
   781  GKKPYECKEC RKTFIQIGHL NQHKRVHTGE RSYNYKKSRK VFRQTAHLAH HQRIHTGESS
   841  TCPSLPSTSN PVDLFPKFLW NPSSLPSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

retina: 10 nTPM
ovary: 9.1 nTPM
spinal cord: 7.7 nTPM
cerebellum: 7.5 nTPM
hypothalamus: 7.4 nTPM
testis: 7.1 nTPM

Single-cell type

adrenal medulla cells: 32 nCPM
cardiomyocytes: 24 nCPM
medullary thymic epithelial cells: 17 nCPM
retinal horizontal cells: 14 nCPM
thyrotrophs: 13 nCPM
podocytes: 13 nCPM

Immune cell

eosinophil: 1.4 nTPM
T-reg: 1.3 nTPM
naive B-cell: 1.1 nTPM
MAIT T-cell: 0.8 nTPM
memory CD4 T-cell: 0.8 nTPM
NK-cell: 0.8 nTPM

Brain region

white matter: 15 nTPM
cerebellum: 15 nTPM
pons: 15 nTPM
hippocampal formation: 15 nTPM
hypothalamus: 14 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 1.11
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP28 as an antibody target. Whether an autoantibody or antibody against ZFP28 could matter depends on whether native ZFP28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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