Seroatlas · Human Serome Atlas

ZFAND6

AN1-type zinc finger protein 6

Also known as: AWP1, ZA20D3, ZFAN6_HUMAN, ZFAND5B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6FIF0
Gene: ZFAND6
Ensembl: ENSG00000086666
Chromosome: 15
Canonical length: 208 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q6FIF0|ZFAND6
     1  MAQETNHSQV PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP PATSVSSLSE
    61  SLPVQCTDGS VPEAQSALDS TSSSMQPSPV SNQSLLSESV ASSQLDSTSV DKAVPETEDV
   121  QASVSDTAQQ PSEEQSKSLE KPKQKKNRCF MCRKKVGLTG FECRCGNVYC GVHRYSDVHN
   181  CSYNYKADAA EKIRKENPVV VGEKIQKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFAND6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 128 nTPM

Expression across tissuesHPA

Tissue

testis: 128 nTPM
skeletal muscle: 123 nTPM
liver: 116 nTPM
tongue: 103 nTPM
thyroid gland: 95 nTPM
heart muscle: 85 nTPM

Single-cell type

neutrophils: 918 nCPM
late spermatids: 842 nCPM
early spermatids: 657 nCPM
syncytiotrophoblasts: 634 nCPM
endometrial glandular cells: 628 nCPM
esophageal apical cells: 619 nCPM

Immune cell

basophil: 511 nTPM
eosinophil: 293 nTPM
memory B-cell: 229 nTPM
neutrophil: 219 nTPM
naive B-cell: 177 nTPM
non-classical monocyte: 169 nTPM

Brain region

white matter: 89 nTPM
cerebellum: 84 nTPM
spinal cord: 83 nTPM
medulla oblongata: 78 nTPM
hypothalamus: 77 nTPM
choroid plexus: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.46
gnomAD missense Z: 0.99
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFAND6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFAND6 as an antibody target. Whether an autoantibody or antibody against ZFAND6 could matter depends on whether native ZFAND6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFAND6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFAND6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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