Seroatlas · Human Serome Atlas

ZDHHC1

Palmitoyltransferase ZDHHC1

Also known as: C16orf1, HSU90653, ZDHC1_HUMAN, ZNF377

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WTX9
Gene
ZDHHC1
Ensembl
ENSG00000159714
Chromosome
16
Canonical length
485 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables protein-cysteine S-palmitoyltransferase activity. Involved in antiviral innate immune response; protein palmitoylation; and regulation of defense response. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q8WTX9|ZDHHC1
     1  MYKMNICNKP SNKTAPEKSV WTAPAQPSGP SPELQGQRSR RNGWSWPPHP LQIVAWLLYL
    61  FFAVIGFGIL VPLLPHHWVP AGYACMGAIF AGHLVVHLTA VSIDPADANV RDKSYAGPLP
   121  IFNRSQHAHV IEDLHCNLCN VDVSARSKHC SACNKCVCGF DHHCKWLNNC VGERNYRLFL
   181  HSVASALLGV LLLVLVATYV FVEFFVNPMR LRTNRHFEVL KNHTDVWFVF LPAAPVETQA
   241  PAILALAALL ILLGLLSTAL LGHLLCFHIY LMWHKLTTYE YIVQHRPPQE AKGVHRELES
   301  CPPKMRPIQE MEFYMRTFRH MRPEPPGQAG PAAVNAKHSR PASPDPTPGR RDCAGPPVQV
   361  EWDRKKPLPW RSPLLLLAMW GPQAPPCLCR KRGRGACIKC ERLRPRIRRR GLGPPAAAPA
   421  RRRIPRTPAL CTPLALPAPT TRRRQSPWTR FQWRRRAWAA PLWPPRGAGA DSPRWRGRRV
   481  RPPFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 21 nTPM
  • cervix: 19 nTPM
  • ovary: 17 nTPM
  • testis: 17 nTPM
  • fallopian tube: 16 nTPM
  • endometrium: 16 nTPM

Single-cell type

  • late spermatids: 306 nCPM
  • late primary spermatocytes: 169 nCPM
  • respiratory ciliated cells: 150 nCPM
  • early spermatids: 133 nCPM
  • endometrial ciliated cells: 108 nCPM
  • fallopian tube ciliated cells: 107 nCPM

Immune cell

  • intermediate monocyte: 1.4 nTPM
  • non-classical monocyte: 1.3 nTPM
  • classical monocyte: 1 nTPM
  • myeloid DC: 0.8 nTPM
  • total PBMC: 0.3 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • choroid plexus: 17 nTPM
  • midbrain: 16 nTPM
  • medulla oblongata: 12 nTPM
  • spinal cord: 12 nTPM
  • thalamus: 11 nTPM
  • cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
gnomAD missense Z
1.14
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC1 as an antibody target. Whether an autoantibody or antibody against ZDHHC1 could matter depends on whether native ZDHHC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZDHHC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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