Seroatlas · Human Serome Atlas

ZCCHC7

Zinc finger CCHC domain-containing protein 7

Also known as: AIR1, FLJ22611, ZCHC7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3Z6
Gene: ZCCHC7
Ensembl: ENSG00000147905
Chromosome: 9
Canonical length: 543 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in nuclear RNA surveillance. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q8N3Z6|ZCCHC7
     1  MMFGGYETIE AYEDDLYRDE SSSELSVDSE VEFQLYSQIH YAQDLDDVIR EEEHEEKNSG
    61  NSESSSSKPN QKKLIVLSDS EVIQLSDGSE VITLSDEDSI YRCKGKNVRV QAQENAHGLS
   121  SSLQSNELVD KKCKSDIEKP KSEERSGVIR EVMIIEVSSS EEEESTISEG DNVESWMLLG
   181  CEVDDKDDDI LLNLVGCENS VTEGEDGINW SISDKDIEAQ IANNRTPGRW TQRYYSANKN
   241  IICRNCDKRG HLSKNCPLPR KVRRCFLCSR RGHLLYSCPA PLCEYCPVPK MLDHSCLFRH
   301  SWDKQCDRCH MLGHYTDACT EIWRQYHLTT KPGPPKKPKT PSRPSALAYC YHCAQKGHYG
   361  HECPEREVYD PSPVSPFICY YDDKYEIQER EKRLKQKIKV LKKNGVIPEP SKLPYIKAAN
   421  ENPHHDIRKG RASWKSNRWP QENKETQKEM KNKNRNWEKH RKADRHREVD EDFPRGPKTY
   481  SSPGSFKTQK PSKPFHRSSH YHTSREDKSP KEGKRGKQKK KERCWEDDDN DNLFLIKQRK
   541  KKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCCHC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

tonsil: 23 nTPM
lymph node: 22 nTPM
ovary: 15 nTPM
bone marrow: 13 nTPM
breast: 12 nTPM
appendix: 12 nTPM

Single-cell type

pituicytes/fscs: 1,202 nCPM
b-cells: 932 nCPM
choroid plexus epithelial cells: 799 nCPM
lactotrophs: 794 nCPM
somatotrophs: 729 nCPM
thyrotrophs: 615 nCPM

Immune cell

naive B-cell: 49 nTPM
memory B-cell: 33 nTPM
eosinophil: 21 nTPM
naive CD4 T-cell: 19 nTPM
NK-cell: 19 nTPM
naive CD8 T-cell: 17 nTPM

Brain region

cerebellum: 55 nTPM
cerebral cortex: 34 nTPM
white matter: 34 nTPM
thalamus: 32 nTPM
pons: 29 nTPM
midbrain: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCHC-type
Zinc finger, CCHC-type superfamily
Zinc knuckle
TRAMP complex component and AT-rich DNA-binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZCCHC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SUMO1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCCHC7 as an antibody target. Whether an autoantibody or antibody against ZCCHC7 could matter depends on whether native ZCCHC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCCHC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCCHC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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