Seroatlas · Human Serome Atlas

ZC3HC1

Zinc finger C3HC-type protein 1

Also known as: NIPA, ZC3C1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86WB0
Gene
ZC3HC1
Ensembl
ENSG00000091732
Chromosome
7
Canonical length
502 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>Q86WB0|ZC3HC1
     1  MAAPCEGQAF AVGVEKNWGA VVRSPEGTPQ KIRQLIDEGI APEEGGVDAK DTSATSQSVN
    61  GSPQAEQPSL ESTSKEAFFS RVETFSSLKW AGKPFELSPL VCAKYGWVTV ECDMLKCSSC
   121  QAFLCASLQP AFDFDRYKQR CAELKKALCT AHEKFCFWPD SPSPDRFGML PLDEPAILVS
   181  EFLDRFQSLC HLDLQLPSLR PEDLKTMCLT EDKISLLLHL LEDELDHRTD ERKTTIKLGS
   241  DIQVHVTACI LSVCGWACSS SLESMQLSLI TCSQCMRKVG LWGFQQIESS MTDLDASFGL
   301  TSSPIPGLEG RPERLPLVPE SPRRMMTRSQ DATFSPGSEQ AEKSPGPIVS RTRSWDSSSP
   361  VDRPEPEAAS PTTRTRPVTR SMGTGDTPGL EVPSSPLRKA KRARLCSSSS SDTSSRSFFD
   421  PTSQHRDWCP WVNITLGKES RENGGTEPDA SAPAEPGWKA VLTILLAHKQ SSQPAETDSM
   481  SLSEKSRKVF RIFRQWESLC SC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3HC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 31 nTPM
  • tongue: 27 nTPM
  • heart muscle: 17 nTPM
  • liver: 16 nTPM
  • testis: 16 nTPM
  • spleen: 13 nTPM

Single-cell type

  • myonuclei: 71 nCPM
  • early primary spermatocytes: 52 nCPM
  • sertoli cells: 49 nCPM
  • late primary spermatocytes: 48 nCPM
  • choroid plexus epithelial cells: 44 nCPM
  • adipocytes: 43 nCPM

Immune cell

  • memory B-cell: 40 nTPM
  • naive B-cell: 37 nTPM
  • naive CD4 T-cell: 35 nTPM
  • basophil: 35 nTPM
  • myeloid DC: 31 nTPM
  • T-reg: 31 nTPM

Brain region

  • hypothalamus: 9.2 nTPM
  • thalamus: 9.1 nTPM
  • choroid plexus: 8.6 nTPM
  • white matter: 8.4 nTPM
  • midbrain: 8.3 nTPM
  • medulla oblongata: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
1.1
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • NuBaID, N-terminal domain
  • NuBaID, C-terminal domain
  • NuBaID N-terminal domain (aka zf-C3HC)
  • NuBaID, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3HC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3HC1 as an antibody target. Whether an autoantibody or antibody against ZC3HC1 could matter depends on whether native ZC3HC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3HC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3HC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZC3HC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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