YDJC
Carbohydrate deacetylase
Also known as: YDJC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8MPS7
- Gene
- YDJC
- Ensembl
- ENSG00000161179
- Chromosome
- 22
- Canonical length
- 323 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Vesicles,Cytosol
OverviewNCBI Gene
Predicted to enable deacetylase activity and magnesium ion binding activity. Predicted to be involved in carbohydrate metabolic process. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
323 residues, UniProt reviewed canonical sequence.
>A8MPS7|YDJC
1 MSRPRMRLVV TADDFGYCPR RDEGIVEAFL AGAVTSVSLL VNGAATESAA ELARRHSIPT
61 GLHANLSEGR PVGPARRGAS SLLGPEGFFL GKMGFREAVA AGDVDLPQVR EELEAQLSCF
121 RELLGRAPTH ADGHQHVHVL PGVCQVFAEA LQAYGVRFTR LPLERGVGGC TWLEAPARAF
181 ACAVERDARA AVGPFSRHGL RWTDAFVGLS TCGRHMSAHR VSGALARVLE GTLAGHTLTA
241 ELMAHPGYPS VPPTGGCGEG PDAFSCSWER LHELRVLTAP TLRAQLAQDG VQLCALDDLD
301 SKRPGEEVPC EPTLEPFLEP SLLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against YDJC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 9.7 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 9.7 nTPM
- kidney: 7.9 nTPM
- esophagus: 7 nTPM
- liver: 6.9 nTPM
- hippocampal formation: 6.2 nTPM
- thyroid gland: 6.1 nTPM
Single-cell type
- extravillous trophoblasts: 84 nCPM
- esophageal basal cells: 83 nCPM
- migrating cytotrophoblasts: 70 nCPM
- oocytes: 51 nCPM
- cytotrophoblasts: 49 nCPM
- esophageal suprabasal cells: 47 nCPM
Immune cell
- NK-cell: 22 nTPM
- memory B-cell: 18 nTPM
- naive B-cell: 18 nTPM
- myeloid DC: 18 nTPM
- T-reg: 15 nTPM
- classical monocyte: 15 nTPM
Brain region
- white matter: 3.9 nTPM
- medulla oblongata: 3.8 nTPM
- cerebral cortex: 2.9 nTPM
- hippocampal formation: 2.9 nTPM
- pons: 2.8 nTPM
- basal ganglia: 2.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0.06
- gnomAD missense Z
- 1.41
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Glycoside hydrolase/deacetylase, beta/alpha-barrel
- Carbohydrate deacetylase YdjC-like
- YdjC-like protein
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads YDJC as an antibody target. Whether an autoantibody or antibody against YDJC could matter depends on whether native YDJC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
YDJC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label YDJC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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