Seroatlas · Human Serome Atlas

WNT10B

Protein Wnt-10b

Also known as: SHFM6, WN10B_HUMAN, WNT-12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00744
Gene
WNT10B
Ensembl
ENSG00000169884
Chromosome
12
Canonical length
389 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Subcellular location
Golgi apparatus
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>O00744|WNT10B
     1  MLEEPRPRPP PSGLAGLLFL ALCSRALSNE ILGLKLPGEP PLTANTVCLT LSGLSKRQLG
    61  LCLRNPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG GRLPHHSAIL KRGFRESAFS
   121  FSMLAAGVMH AVATACSLGK LVSCGCGWKG SGEQDRLRAK LLQLQALSRG KSFPHSLPSP
   181  GPGSSPSPGP QDTWEWGGCN HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT
   241  ENLKRKCKCH GTSGSCQFKT CWRAAPEFRA VGAALRERLG RAIFIDTHNR NSGAFQPRLR
   301  PRRLSGELVY FEKSPDFCER DPTMGSPGTR GRACNKTSRL LDGCGSLCCG RGHNVLRQTR
   361  VERCHCRFHW CCYVLCDECK VTEWVNVCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 39 nTPM
  • cerebral cortex: 26 nTPM
  • amygdala: 19 nTPM
  • hippocampal formation: 13 nTPM
  • hypothalamus: 8.2 nTPM
  • midbrain: 4.4 nTPM

Single-cell type

  • extravillous trophoblasts: 31 nCPM
  • brain inhibitory neurons: 16 nCPM
  • brain excitatory neurons: 9.3 nCPM
  • fibro-adipogenic progenitors: 8.1 nCPM
  • pituitary stem cells: 6.7 nCPM
  • hepatic stellate cells: 6.5 nCPM

Immune cell

  • gdT-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebral cortex: 32 nTPM
  • basal ganglia: 25 nTPM
  • amygdala: 21 nTPM
  • hippocampal formation: 16 nTPM
  • hypothalamus: 15 nTPM
  • white matter: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WNT10B.

Disease | AllUniProt

Conditions WNT10B is implicated in, by any mechanism.

Disease | GeneticClinVar

25 pathogenic / likely-pathogenic of 138 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Split hand-foot malformation 6
  • Tooth agenesis, selective, 8
  • WNT10B-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
1.05
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WNT10B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT10B as an antibody target. Whether an autoantibody or antibody against WNT10B could matter depends on whether native WNT10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT10B is annotated as secreted, so native WNT10B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WNT10B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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