Seroatlas · Human Serome Atlas

WNT10A

Protein Wnt-10a

Also known as: WN10A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZT5
Gene
WNT10A
Ensembl
ENSG00000135925
Chromosome
2
Canonical length
417 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q9GZT5|WNT10A
     1  MGSAHPRPWL RLRPQPQPRP ALWVLLFFLL LLAAAMPRSA PNDILDLRLP PEPVLNANTV
    61  CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF RDQRWNCSSL ETRNKIPYES
   121  PIFSRGFRES AFAYAIAAAG VVHAVSNACA LGKLKACGCD ASRRGDEEAF RRKLHRLQLD
   181  ALQRGKGLSH GVPEHPALPT ASPGLQDSWE WGGCSPDMGF GERFSKDFLD SREPHRDIHA
   241  RMRLHNNRVG RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RSRFHRATLI
   301  RPHNRNGGQL EPGPAGAPSP APGAPGPRRR ASPADLVYFE KSPDFCEREP RLDSAGTVGR
   361  LCNKSSAGSD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC FVVCEECRIT EWVSVCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
8.4 nTPM

Expression across tissuesHPA

Tissue

  • skin: 8.4 nTPM
  • esophagus: 7.9 nTPM
  • pituitary gland: 5 nTPM
  • duodenum: 3.5 nTPM
  • placenta: 3.2 nTPM
  • vagina: 3.2 nTPM

Single-cell type

  • pdcs: 52 nCPM
  • plasma cells: 29 nCPM
  • basal keratinocytes: 27 nCPM
  • esophageal basal cells: 26 nCPM
  • epididymal basal cells: 17 nCPM
  • retinal bipolar cells: 11 nCPM

Immune cell

  • plasmacytoid DC: 6.2 nTPM
  • T-reg: 1 nTPM
  • naive B-cell: 0.7 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM

Brain region

  • basal ganglia: 3.4 nTPM
  • cerebral cortex: 2.8 nTPM
  • hippocampal formation: 2.5 nTPM
  • thalamus: 1.6 nTPM
  • white matter: 1.4 nTPM
  • midbrain: 1.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WNT10A.

Disease | AllUniProt

Conditions WNT10A is implicated in, by any mechanism.

Disease | GeneticClinVar

117 pathogenic / likely-pathogenic of 615 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Odonto-onycho-dermal dysplasia
  • Tooth agenesis, selective, 4
  • Schöpf-Schulz-Passarge syndrome
  • Inborn genetic diseases
  • WNT10A-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
-0.45
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WNT10A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT10A as an antibody target. Whether an autoantibody or antibody against WNT10A could matter depends on whether native WNT10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT10A is annotated as secreted, so native WNT10A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WNT10A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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