Seroatlas · Human Serome Atlas

WDR76

WD repeat-containing protein 76

Also known as: FLJ12973, WDR76_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H967
Gene: WDR76
Ensembl: ENSG00000092470
Chromosome: 15
Canonical length: 626 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Nuclear bodies

OverviewNCBI Gene

Enables enzyme binding activity. Involved in DNA damage response. Located in heterochromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q9H967|WDR76
     1  MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY LAPFSLSNYQ
    61  LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN TSSKAESTLQ NSSSAVHTES
   121  NKLQPKRTAD AMNLSVDVES SQDGDSDEDT TPSLDFSGLS PYERKRLKNI SENADFFASL
   181  QLSESAARLR EMIEKRQPPK SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV
   241  ADETPLLPPG PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG
   301  MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE DGVYVFHPHS
   361  QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR NERSSFSSFD FLAEDASTLI
   421  VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK IRTVHVHPVH RQYFITAGLR DTHIYDARRL
   481  NSRRSQPLIS LTEHTKSIAS AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH
   541  NTFTGRWLTR FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA
   601  MHPTRYILAG GNSSGKIHVF MNEKSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR76 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

tonsil: 20 nTPM
lymph node: 18 nTPM
thymus: 18 nTPM
bone marrow: 18 nTPM
appendix: 7.9 nTPM
retina: 5.8 nTPM

Single-cell type

erythrocyte progenitors: 93 nCPM
oocytes: 83 nCPM
monocyte progenitors: 70 nCPM
neutrophil progenitors: 65 nCPM
megakaryocyte progenitors: 62 nCPM
early primary spermatocytes: 56 nCPM

Immune cell

T-reg: 6.7 nTPM
NK-cell: 4.8 nTPM
memory CD4 T-cell: 4.6 nTPM
MAIT T-cell: 4.1 nTPM
gdT-cell: 3.9 nTPM
naive CD4 T-cell: 3.8 nTPM

Brain region

cerebellum: 11 nTPM
cerebral cortex: 4.2 nTPM
pons: 3.5 nTPM
medulla oblongata: 3.4 nTPM
thalamus: 3.4 nTPM
white matter: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
WD repeat-containing DNA damage-binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR76 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR76 as an antibody target. Whether an autoantibody or antibody against WDR76 could matter depends on whether native WDR76 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR76 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR76 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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