Seroatlas · Human Serome Atlas

WDR4

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Also known as: TRM82, TRMT82, WDR4_HUMAN, Wuho

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57081
Gene
WDR4
Ensembl
ENSG00000160193
Chromosome
21
Canonical length
412 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>P57081|WDR4
     1  MAGSVGLALC GQTLVVRGGS RFLATSIASS DDDSLFIYDC SAAEKKSQEN KGEDAPLDQG
    61  SGAILASTFS KSGSYFALTD DSKRLILFRT KPWQCLSVRT VARRCTALTF IASEEKVLVA
   121  DKSGDVYSFS VLEPHGCGRL ELGHLSMLLD VAVSPDDRFI LTADRDEKIR VSWAAAPHSI
   181  ESFCLGHTEF VSRISVVPTQ PGLLLSSSGD GTLRLWEYRS GRQLHCCHLA SLQELVDPQA
   241  PQKFAASRIA FWCQENCVAL LCDGTPVVYI FQLDARRQQL VYRQQLAFQH QVWDVAFEET
   301  QGLWVLQDCQ EAPLVLYRPV GDQWQSVPES TVLKKVSGVL RGNWAMLEGS AGADASFSSL
   361  YKATFDNVTS YLKKKEERLQ QQLEKKQRRR SPPPGPDGHA KKMRPGEATL SC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
8.8 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 8.8 nTPM
  • lymph node: 8.6 nTPM
  • tonsil: 6.9 nTPM
  • appendix: 6.8 nTPM
  • bone marrow: 6.3 nTPM
  • skeletal muscle: 6.3 nTPM

Single-cell type

  • endometrial ciliated cells: 74 nCPM
  • oocytes: 60 nCPM
  • erythrocyte progenitors: 52 nCPM
  • esophageal basal cells: 44 nCPM
  • migrating cytotrophoblasts: 39 nCPM
  • extravillous trophoblasts: 30 nCPM

Immune cell

  • myeloid DC: 7.1 nTPM
  • intermediate monocyte: 6.8 nTPM
  • memory B-cell: 5.4 nTPM
  • naive B-cell: 4.9 nTPM
  • T-reg: 4.4 nTPM
  • non-classical monocyte: 4.2 nTPM

Brain region

  • cerebral cortex: 11 nTPM
  • pons: 11 nTPM
  • medulla oblongata: 10 nTPM
  • white matter: 10 nTPM
  • thalamus: 9.8 nTPM
  • midbrain: 9.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR4.

Disease | AllUniProt

Conditions WDR4 is implicated in, by any mechanism.

  • Galloway-Mowat syndrome 6 (GAMOS6) MIM:618347
  • Microcephaly, growth deficiency, seizures, and brain malformations (MIGSB) MIM:618346

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 356 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
-1.02
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR4 as an antibody target. Whether an autoantibody or antibody against WDR4 could matter depends on whether native WDR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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