Seroatlas · Human Serome Atlas

METTL1

tRNA (guanine-N(7)-)-methyltransferase

Also known as: C12orf1, TRM8, TRMB_HUMAN, TRMT8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBP6
Gene
METTL1
Ensembl
ENSG00000037897
Chromosome
12
Canonical length
276 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q9UBP6|METTL1
     1  MAAETRNVAG AEAPPPQKRY YRQRAHSNPM ADHTLRYPVK PEEMDWSELY PEFFAPLTQN
    61  QSHDDPKDKK EKRAQAQVEF ADIGCGYGGL LVELSPLFPD TLILGLEIRV KVSDYVQDRI
   121  RALRAAPAGG FQNIACLRSN AMKHLPNFFY KGQLTKMFFL FPDPHFKRTK HKWRIISPTL
   181  LAEYAYVLRV GGLVYTITDV LELHDWMCTH FEEHPLFERV PLEDLSEDPV VGHLGTSTEE
   241  GKKVLRNGGK NFPAIFRRIQ DPVLQAVTSQ TSLPGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 27 nTPM
  • adrenal gland: 23 nTPM
  • kidney: 21 nTPM
  • epididymis: 20 nTPM
  • liver: 18 nTPM
  • skeletal muscle: 16 nTPM

Single-cell type

  • late spermatids: 13 nCPM
  • differentiating spermatogonia: 11 nCPM
  • early spermatids: 11 nCPM
  • fallopian secretory cells: 9.7 nCPM
  • epicardial cells: 9.1 nCPM
  • parietal cells: 8.8 nCPM

Immune cell

  • MAIT T-cell: 28 nTPM
  • plasmacytoid DC: 19 nTPM
  • myeloid DC: 16 nTPM
  • naive CD4 T-cell: 14 nTPM
  • naive CD8 T-cell: 13 nTPM
  • NK-cell: 13 nTPM

Brain region

  • choroid plexus: 6.2 nTPM
  • thalamus: 5.5 nTPM
  • hypothalamus: 5 nTPM
  • midbrain: 4.8 nTPM
  • medulla oblongata: 4.6 nTPM
  • cerebral cortex: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.24
DepMap mean gene effect
-0.46
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • tRNA binding
  • internal mRNA (guanine-N7-)-methyltransferase activity
  • tRNA (guanine(46)-N7)-methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL1 as an antibody target. Whether an autoantibody or antibody against METTL1 could matter depends on whether native METTL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/METTL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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