Seroatlas · Human Serome Atlas

VSTM4

V-set and transmembrane domain-containing protein 4

Also known as: C10orf72, FLJ31737, VSTM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IW00
Gene: VSTM4
Ensembl: ENSG00000165633
Chromosome: 10
Canonical length: 320 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Vesicles
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including endothelial cell proliferation; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q8IW00|VSTM4
     1  MRLLALAAAA LLARAPAPEV CAALNVTVSP GPVVDYLEGE NATLLCHVSQ KRRKDSLLAV
    61  RWFFAHSFDS QEALMVKMTK LRVVQYYGNF SRSAKRRRLR LLEEQRGALY RLSVLTLQPS
   121  DQGHYVCRVQ EISRHRNKWT AWSNGSSATE MRVISLKASE ESSFEKTKET WAFFEDLYVY
   181  AVLVCCVGIL SILLFMLVIV WQSVFNKRKS RVRHYLVKCP QNSSGETVTS VTSLAPLQPK
   241  KGKRQKEKPD IPPAVPAKAP IAPTFHKPKL LKPQRKVTLP KIAEENLTYA ELELIKPHRA
   301  AKGAPTSTVY AQILFEENKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSTM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 39 nTPM
ovary: 37 nTPM
thyroid gland: 26 nTPM
parathyroid gland: 25 nTPM
cervix: 21 nTPM
blood vessel: 19 nTPM

Single-cell type

adrenal cortex cells: 367 nCPM
late spermatids: 204 nCPM
early spermatids: 162 nCPM
granulosa cells: 103 nCPM
alveolar cells type 2: 95 nCPM
pericytes: 90 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.5 nTPM
naive B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

midbrain: 18 nTPM
white matter: 17 nTPM
pons: 17 nTPM
medulla oblongata: 17 nTPM
basal ganglia: 17 nTPM
spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.03
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSTM4 as an antibody target. Whether an autoantibody or antibody against VSTM4 could matter depends on whether native VSTM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSTM4 is annotated at the cell surface, where native VSTM4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VSTM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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