Seroatlas · Human Serome Atlas

VSTM2B

V-set and transmembrane domain-containing protein 2B

Also known as: VTM2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NLU5
Gene: VSTM2B
Ensembl: ENSG00000187135
Chromosome: 19
Canonical length: 285 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>A6NLU5|VSTM2B
     1  MEQRNRLGAL GYLPPLLLHA LLLFVADAAF TEVPKDVTVR EGDDIEMPCA FRASGATSYS
    61  LEIQWWYLKE PPRELLHELA LSVPGARSKV TNKDATKIST VRVQGNDISH RLRLSAVRLQ
   121  DEGVYECRVS DYSDDDTQEH KAQAMLRVLS RFAPPNMQAA EAVSHIQSSG PRRHGPASAA
   181  NANNAGAASR TTSEPGRGDK SPPPGSPPAA IDPAVPEAAA ASAAHTPTTT VAAAAAASSA
   241  SPPSGQAVLL RQRHGSGTGR SYTTDPLLSL LLLALHKFLR LLLGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSTM2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 32 nTPM
basal ganglia: 30 nTPM
amygdala: 29 nTPM
hippocampal formation: 26 nTPM
cerebellum: 25 nTPM
midbrain: 25 nTPM

Single-cell type

retinal amacrine cells: 163 nCPM
oligodendrocytes: 136 nCPM
oligodendrocyte progenitor cells: 120 nCPM
retinal bipolar cells: 61 nCPM
brain inhibitory neurons: 55 nCPM
retinal horizontal cells: 38 nCPM

Immune cell

gdT-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 89 nTPM
white matter: 78 nTPM
amygdala: 64 nTPM
thalamus: 56 nTPM
medulla oblongata: 55 nTPM
basal ganglia: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSTM2B as an antibody target. Whether an autoantibody or antibody against VSTM2B could matter depends on whether native VSTM2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSTM2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VSTM2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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