Seroatlas · Human Serome Atlas

VSIG10L

V-set and immunoglobulin domain-containing protein 10-like

Also known as: VS10L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VR7
Gene: VSIG10L
Ensembl: ENSG00000186806
Chromosome: 19
Canonical length: 867 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

867 residues, UniProt reviewed canonical sequence.

>Q86VR7|VSIG10L
     1  MDNPQALPLF LLLASLVGIL TLRASSGLQQ TNFSSAFSSD SKSSSQGLGV EVPSIKPPSW
    61  KVPDQFLDSK ASAGISDSSW FPEALSSNMS GSFWSNVSAE GQDLSPVSPF SETPGSEVFP
   121  DISDPQVPAK DPKPSFTVKT PASNISTQVS HTKLSVEAPD SKFSPDDMDL KLSAQSPESK
   181  FSAETHSAAS FPQQVGGPLA VLVGTTIRLP LVPIPNPGPP TSLVVWRRGS KVLAAGGLGP
   241  GAPLISLDPA HRDHLRFDQA RGVLELASAQ LDDAGVYTAE VIRAGVSQQT HEFTVGVYEP
   301  LPQLSVQPKA PETEEGAAEL RLRCLGWGPG RGELSWSRDG RALEAAESEG AETPRMRSEG
   361  DQLLIVRPVR SDHARYTCRV RSPFGHREAA ADVSVFYGPD PPTITVSSDR DAAPARFVTA
   421  GSNVTLRCAA ASRPPADITW SLADPAEAAV PAGSRLLLPA VGPGHAGTYA CLAANPRTGR
   481  RRRSLLNLTV ADLPPGAPQC SVEGGPGDRS LRFRCSWPGG APAASLQFQG LPEGIRAGPV
   541  SSVLLAAVPA HPRLSGVPIT CLARHLVATR TCTVTPEAPR EVLLHPLVAE TRLGEAEVAL
   601  EASGCPPPSR ASWAREGRPL APGGGSRLRL SQDGRKLHIG NFSLDWDLGN YSVLCSGALG
   661  AGGDQITLIG PSISSWRLQR ARDAAVLTWD VERGALISSF EIQAWPDGPA LGRTSTYRDW
   721  VSLLILGPQE RSAVVPLPPR NPGTWTFRIL PILGGQPGTP SQSRVYRAGP TLSHGAIAGI
   781  VLGSLLGLAL LAVLLLLCIC CLCRFRGKTP EKKKHPSTLV PVVTPSEKKM HSVTPVEISW
   841  PLDLKVPLED HSSTRAYQAQ TPVQLSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSIG10L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

esophagus: 69 nTPM
vagina: 26 nTPM
salivary gland: 25 nTPM
cervix: 17 nTPM
skin: 12 nTPM
tonsil: 6.6 nTPM

Single-cell type

esophageal apical cells: 1,033 nCPM
esophageal suprabasal cells: 85 nCPM
suprabasal keratinocytes: 39 nCPM
salivary acinar cells: 17 nCPM
oocytes: 9.2 nCPM
retinal horizontal cells: 8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 3.1 nTPM
pons: 2.9 nTPM
cerebellum: 2.8 nTPM
white matter: 2.8 nTPM
hypothalamus: 2.7 nTPM
cerebral cortex: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 2.23
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSIG10L as an antibody target. Whether an autoantibody or antibody against VSIG10L could matter depends on whether native VSIG10L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSIG10L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VSIG10L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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