Seroatlas · Human Serome Atlas

VSIG10

V-set and immunoglobulin domain-containing protein 10

Also known as: VSI10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0Z9
Gene: VSIG10
Ensembl: ENSG00000176834
Chromosome: 12
Canonical length: 540 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centriolar satellite,Cytosol

OverviewNCBI Gene

Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion and synapse assembly. Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q8N0Z9|VSIG10
     1  MAAGGSAPEP RVLVCLGALL AGWVAVGLEA VVIGEVHENV TLHCGNISGL RGQVTWYRNN
    61  SEPVFLLSSN SSLRPAEPRF SLVDATSLHI ESLSLGDEGI YTCQEILNVT QWFQVWLQVA
   121  SGPYQIEVHI VATGTLPNGT LYAARGSQVD FSCNSSSRPP PVVEWWFQAL NSSSESFGHN
   181  LTVNFFSLLL ISPNLQGNYT CLALNQLSKR HRKVTTELLV YYPPPSAPQC WAQMASGSFM
   241  LQLTCRWDGG YPDPDFLWIE EPGGVIVGKS KLGVEMLSES QLSDGKKFKC VTSHIVGPES
   301  GASCMVQIRG PSLLSEPMKT CFTGGNVTLT CQVSGAYPPA KILWLRNLTQ PEVIIQPSSR
   361  HLITQDGQNS TLTIHNCSQD LDEGYYICRA DSPVGVREME IWLSVKEPLN IGGIVGTIVS
   421  LLLLGLAIIS GLLLHYSPVF CWKVGNTSRG QNMDDVMVLV DSEEEEEEEE EEEEDAAVGE
   481  QEGAREREEL PKEIPKQDHI HRVTALVNGN IEQMGNGFQD LQDDSSEEQS DIVQEEDRPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSIG10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

small intestine: 23 nTPM
skeletal muscle: 16 nTPM
rectum: 15 nTPM
duodenum: 13 nTPM
colon: 13 nTPM
thyroid gland: 11 nTPM

Single-cell type

sertoli cells: 159 nCPM
enterocytes: 156 nCPM
esophageal apical cells: 153 nCPM
adrenal cortex cells: 133 nCPM
myonuclei: 124 nCPM
paneth cells: 108 nCPM

Immune cell

neutrophil: 1 nTPM
eosinophil: 0.6 nTPM
myeloid DC: 0.6 nTPM
classical monocyte: 0.5 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

medulla oblongata: 9.2 nTPM
basal ganglia: 8.1 nTPM
cerebellum: 8.1 nTPM
spinal cord: 8.1 nTPM
thalamus: 7.6 nTPM
midbrain: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cell adhesion molecule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSIG10 as an antibody target. Whether an autoantibody or antibody against VSIG10 could matter depends on whether native VSIG10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSIG10 is annotated at the cell surface, where native VSIG10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VSIG10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...