Seroatlas · Human Serome Atlas

VPREB1

Immunoglobulin iota chain

Also known as: CD179A, VpreB, VPREB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P12018
Gene: VPREB1
Ensembl: ENSG00000169575
Chromosome: 22
Canonical length: 145 aa
Protein class: CD markers, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>P12018|VPREB1
     1  MSWAPVLLML FVYCTGCGPQ PVLHQPPAMS SALGTTIRLT CTLRNDHDIG VYSVYWYQQR
    61  PGHPPRFLLR YFSQSDKSQG PQVPPRFSGS KDVARNRGYL SISELQPEDE AMYYCAMGAR
   121  SSEKEERERE WEEEMEPTAA RTRVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPREB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 28 nTPM
tonsil: 1.3 nTPM
thymus: 1.1 nTPM
lymph node: 0.5 nTPM
small intestine: 0.1 nTPM
testis: 0.1 nTPM

Single-cell type

thymocytes: 61 nCPM
foveolar cells: 1.2 nCPM
hematopoietic stem cells: 1 nCPM
innate lymphoid cells: 1 nCPM
early spermatids: 0.7 nCPM
endometrial secretory cells: 0.3 nCPM

Immune cell

memory B-cell: 5.7 nTPM
naive B-cell: 5.3 nTPM
plasmacytoid DC: 1.2 nTPM
total PBMC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.1
gnomAD missense Z: 0.13
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

immune response

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPREB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IGLL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPREB1 as an antibody target. Whether an autoantibody or antibody against VPREB1 could matter depends on whether native VPREB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPREB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPREB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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