Seroatlas · Human Serome Atlas

IGLL1

Immunoglobulin lambda-like polypeptide 1

Also known as: 14.1, CD179B, IGL5, IGLL, IGLL1_HUMAN, IGVPB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15814
Gene
IGLL1
Ensembl
ENSG00000128322
Chromosome
22
Canonical length
213 aa
Protein class
CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Endoplasmic reticulum
Secretome location
Secreted to blood

OverviewNCBI Gene

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>P15814|IGLL1
     1  MRPGTGQGGL EAPGEPGPNL RQRWPLLLLG LAVVTHGLLR PTAASQSRAL GPGAPGGSSR
    61  SSLRSRWGRF LLQRGSWTGP RCWPRGFQSK HNSVTHVFGS GTQLTVLSQP KATPSVTLFP
   121  PSSEELQANK ATLVCLMNDF YPGILTVTWK ADGTPITQGV EMTTPSKQSN NKYAASSYLS
   181  LTPEQWRSRR SYSCQVMHEG STVEKTVAPA ECS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 66 nTPM
  • testis: 24 nTPM
  • thymus: 9.5 nTPM
  • tonsil: 2 nTPM
  • lymph node: 1.5 nTPM
  • spleen: 0.4 nTPM

Single-cell type

  • late spermatids: 274 nCPM
  • thymocytes: 116 nCPM
  • early spermatids: 98 nCPM
  • late primary spermatocytes: 58 nCPM
  • neutrophil progenitors: 19 nCPM
  • hematopoietic stem cells: 12 nCPM

Immune cell

  • naive B-cell: 15 nTPM
  • memory B-cell: 12 nTPM
  • total PBMC: 1.8 nTPM
  • plasmacytoid DC: 1.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • choroid plexus: 0.7 nTPM
  • cerebellum: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • basal ganglia: 0.4 nTPM
  • hippocampal formation: 0.4 nTPM
  • white matter: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGLL1.

Disease | AllUniProt

Conditions IGLL1 is implicated in, by any mechanism.

  • Agammaglobulinemia 2, autosomal recessive (AGM2) MIM:613500

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0.01
gnomAD missense Z
-0.3
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGLL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLL1 as an antibody target. Whether an autoantibody or antibody against IGLL1 could matter depends on whether native IGLL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLL1 is annotated as secreted, so native IGLL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made.

Canonical record: https://seroatlas.com/gene/IGLL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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