Seroatlas · Human Serome Atlas

VGLL4

Transcription cofactor vestigial-like protein 4

Also known as: KIAA0121, VGLL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14135
Gene: VGLL4
Ensembl: ENSG00000144560
Chromosome: 3
Canonical length: 290 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable transcription coactivator binding activity. Involved in negative regulation of Wnt signaling pathway; negative regulation of cell growth; and negative regulation of hippo signaling. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q14135|VGLL4
     1  METPLDVLSR AASLVHADDE KREAALRGEP RIQTLPVASA LSSHRTGPPP ISPSKRKFSM
    61  EPGDEDLDCD NDHVSKMSRI FNPHLNKTAN GDCRRDPRER SRSPIERAVA PTMSLHGSHL
   121  YTSLPSLGLE QPLALTKNSL DASRPAGLSP TLTPGERQQN RPSVITCASA GARNCNLSHC
   181  PIAHSGCAAP GPASYRRPPS AATTCDPVVE EHFRRSLGKN YKEPEPAPNS VSITGSVDDH
   241  FAKALGDTWL QIKAAKDGAS SSPESASRRG QPASPSAHMV SHSHSPSVVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VGLL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

ovary: 66 nTPM
blood vessel: 64 nTPM
choroid plexus: 46 nTPM
cervix: 45 nTPM
fallopian tube: 43 nTPM
endometrium: 41 nTPM

Single-cell type

choroid plexus epithelial cells: 719 nCPM
podocytes: 370 nCPM
respiratory ionocytes: 368 nCPM
cone photoreceptor cells: 366 nCPM
salivary ionocytes: 336 nCPM
lacrimal acinar cells: 316 nCPM

Immune cell

basophil: 20 nTPM
gdT-cell: 10 nTPM
non-classical monocyte: 9.3 nTPM
memory CD8 T-cell: 9 nTPM
naive CD8 T-cell: 8.6 nTPM
MAIT T-cell: 7 nTPM

Brain region

choroid plexus: 177 nTPM
hippocampal formation: 96 nTPM
cerebral cortex: 94 nTPM
thalamus: 92 nTPM
medulla oblongata: 92 nTPM
white matter: 89 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.07
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coactivator binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

TDU repeat
Transcription cofactor vestigial-like protein 4
Transcription cofactor vestigial-like protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VGLL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VGLL4 as an antibody target. Whether an autoantibody or antibody against VGLL4 could matter depends on whether native VGLL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VGLL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VGLL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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