IRF2BP2

Protein identityUniProt · HPA

UniProt accession

Q7Z5L9

Gene

IRF2BP2

Ensembl

ENSG00000168264

Chromosome

1

Canonical length

587 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

587 residues, UniProt reviewed canonical sequence.

>Q7Z5L9|IRF2BP2
     1  MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE FVIETARQLK
    61  RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG HGGPEAAPRA PQALERYPLA
   121  AAAERPPRLG SDFGSSRPAA SLAQPPTPQP PPVNGILVPN GFSKLEEPPE LNRQSPNPRR
   181  GHAVPPTLVP LMNGSATPLP TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS
   241  VSSSAAVEHE QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN
   301  RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV ARTARKRKPS
   361  PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP PPPTASPHSN RTTPPEAAQN
   421  GQSPMAALIL VADNAGGSHA SKDANQVHST TRRNSNSPPS PSSMNQRRLG PREVGGQGAG
   481  NTGGLEPVHP ASLPDSSLAT SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ
   541  QGASGEVYCP SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRF2BP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

148 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IRF2BP2.

Disease | AllUniProt

Conditions IRF2BP2 is implicated in, by any mechanism.

• Immunodeficiency, common variable, 14 (CVID14) MIM:617765

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 810 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Immunodeficiency, common variable, 14

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.85

gnomAD missense Z

0.62

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• immature B cell differentiation
• negative regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II

Molecular functions

• transcription corepressor activity
• zinc ion binding

Cellular components

• cytoplasm
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Interferon regulatory factor 2-binding protein 1/2-like, zinc finger
• Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily
• Interferon regulatory factor 2-binding protein 1/2-like, C3HC4 zinc finger domain
• IRF-2BP1/2-like, middle domain
• Interferon regulatory factor 2-binding protein zinc finger
• IRF-2BP1/2 C3HC4 zinc finger domain
• IRF-2BP1/2 middle domain

KeywordsUniProt

• Acetylation
• Activator
• Cytoplasm
• Isopeptide bond
• Metal-binding
• Nucleus
• Phosphoprotein
• Repressor
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of IRF2BP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IRF2
• VGLL4