Seroatlas · Human Serome Atlas

VEZF1

Vascular endothelial zinc finger 1

Also known as: DB1, VEZF1_HUMAN, ZNF161

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14119
Gene: VEZF1
Ensembl: ENSG00000136451
Chromosome: 17
Canonical length: 521 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>Q14119|VEZF1
     1  MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ KPQGAPETLK
    61  DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK LVSRPKKTPT TVVPLISTIA
   121  GDSSRTSLVS TIAGILSTVT TSSSGTNPSS SASTTAMPVT QSVKKPSKPV KKNHACEMCG
   181  KAFRDVYHLN RHKLSHSDEK PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG
   241  FSRPDHLSCH VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY
   301  ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ QQQQHVTSWP
   361  GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP FSITSSVSSG TMSNPVTVAA
   421  AMSMRSPVNV SSAVNITSPM NIGHPVTITS PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV
   481  TITSPMNLPT PMTLAAPLNI AMRPVESMPF LPQALPTSPP W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VEZF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

retina: 65 nTPM
bone marrow: 54 nTPM
skeletal muscle: 45 nTPM
tongue: 42 nTPM
fallopian tube: 36 nTPM
thyroid gland: 35 nTPM

Single-cell type

corticotrophs: 119 nCPM
neutrophils: 105 nCPM
fallopian tube ciliated cells: 101 nCPM
epididymal basal cells: 93 nCPM
oligodendrocytes: 92 nCPM
smooth muscle cells: 87 nCPM

Immune cell

non-classical monocyte: 34 nTPM
basophil: 32 nTPM
NK-cell: 31 nTPM
eosinophil: 30 nTPM
neutrophil: 25 nTPM
memory CD8 T-cell: 19 nTPM

Brain region

white matter: 96 nTPM
basal ganglia: 69 nTPM
medulla oblongata: 69 nTPM
midbrain: 60 nTPM
thalamus: 58 nTPM
cerebellum: 57 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VEZF1.

Disease | AllUniProt

Conditions VEZF1 is implicated in, by any mechanism.

Cardiomyopathy, dilated, 1OO (CMD1OO) MIM:620247

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 68 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cardiomyopathy, dilated, 100

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.99
gnomAD missense Z: 2.92
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VEZF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VEZF1 as an antibody target. Whether an autoantibody or antibody against VEZF1 could matter depends on whether native VEZF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VEZF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VEZF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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