Seroatlas · Human Serome Atlas

ARHGAP22

Rho GTPase-activating protein 22

Also known as: RHG22_HUMAN, RhoGAP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z5H3
Gene
ARHGAP22
Ensembl
ENSG00000128805
Chromosome
10
Canonical length
698 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

698 residues, UniProt reviewed canonical sequence.

>Q7Z5H3|ARHGAP22
     1  MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI MKNWQQRWFV
    61  LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK HLFEISPGGA GEREKVPANP
   121  EALLLMASSQ RDMEDWVQAI RRVIWAPLGG GIFGQRLEET VHHERKYGPR LAPLLVEQCV
   181  DFIRERGLTE EGLFRMPGQA NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE
   241  PVVPFARYED FLSCAQLLTK DEGEGTLELA KQVSNLPQAN YNLLRYICKF LDEVQAYSNV
   301  NKMSVQNLAT VFGPNILRPQ VEDPVTIMEG TSLVQHLMTV LIRKHSQLFT APVPEGPTSP
   361  RGGLQCAVGW GSEEVTRDSQ GEPGGPGLPA HRTSSLDGAA VAVLSRTAPT GPGSRCSPGK
   421  KVQTLPSWKS SFRQPRSLSG SPKGGGSSLE VPIISSGGNW LMNGLSSLRG HRRASSGDRL
   481  KDSGSVQRLS TYDNVPAPGL VPGIPSVASM AWSGASSSES SVGGSLSSCT ACRASDSSAR
   541  SSLHTDWALE PSPLPSSSED PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ
   601  GLVTELRAEL CRQRTEYERS VKRIEEGSAD LRKRMSRLEE ELDQEKKKYI MLEIKLRNSE
   661  RAREDAERRN QLLQREMEEF FSTLGSLTVG AKGARAPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 37 nTPM
  • midbrain: 22 nTPM
  • hippocampal formation: 15 nTPM
  • amygdala: 12 nTPM
  • hypothalamus: 12 nTPM
  • cerebral cortex: 8.5 nTPM

Single-cell type

  • microglia: 1,231 nCPM
  • late spermatids: 251 nCPM
  • oligodendrocytes: 247 nCPM
  • early spermatids: 215 nCPM
  • oligodendrocyte progenitor cells: 202 nCPM
  • fibro-adipogenic progenitors: 154 nCPM

Immune cell

  • classical monocyte: 1.1 nTPM
  • myeloid DC: 0.9 nTPM
  • naive B-cell: 0.6 nTPM
  • total PBMC: 0.3 nTPM
  • non-classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • medulla oblongata: 40 nTPM
  • white matter: 36 nTPM
  • pons: 33 nTPM
  • cerebellum: 28 nTPM
  • midbrain: 26 nTPM
  • spinal cord: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.6
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP22 as an antibody target. Whether an autoantibody or antibody against ARHGAP22 could matter depends on whether native ARHGAP22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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