Seroatlas · Human Serome Atlas

VCF1

Protein VCF1

Also known as: FAM104A, FLJ14775, VCF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969W3
Gene: VCF1
Ensembl: ENSG00000133193
Chromosome: 17
Canonical length: 186 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for VCF1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>Q969W3|VCF1
     1  MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV PSLRGAAPRS
    61  FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF QDSWDTESSG SDSGGSSSSS
   121  SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ PVPEQSALCQ GLYFHINQTL REAHFHSLQH
   181  RGRPLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VCF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

testis: 93 nTPM
bone marrow: 42 nTPM
skin: 20 nTPM
thymus: 20 nTPM
stomach: 19 nTPM
lymph node: 17 nTPM

Single-cell type

late spermatids: 2,602 nCPM
early spermatids: 1,447 nCPM
late primary spermatocytes: 786 nCPM
syncytiotrophoblasts: 416 nCPM
cytotrophoblasts: 156 nCPM
platelets: 143 nCPM

Immune cell

T-reg: 93 nTPM
eosinophil: 64 nTPM
basophil: 64 nTPM
total PBMC: 61 nTPM
neutrophil: 59 nTPM
NK-cell: 57 nTPM

Brain region

cerebellum: 29 nTPM
white matter: 21 nTPM
cerebral cortex: 21 nTPM
thalamus: 20 nTPM
hippocampal formation: 19 nTPM
basal ganglia: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.25
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Methylation

InteractionsUniProt · HPA

Protein binding partners of VCF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VCF1 as an antibody target. Whether an autoantibody or antibody against VCF1 could matter depends on whether native VCF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VCF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VCF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...