Seroatlas · Human Serome Atlas

UBXN2B

UBX domain-containing protein 2B

Also known as: p37, UBX2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14CS0
Gene: UBXN2B
Ensembl: ENSG00000215114
Chromosome: 8
Canonical length: 331 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable ubiquitin binding activity. Involved in establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and spindle pole centrosome. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q14CS0|UBXN2B
     1  MAEGGGPEPG EQERRSSGPR PPSARDLQLA LAELYEDEVK CKSSKSNRPK ATVFKSPRTP
    61  PQRFYSSEHE YSGLNIVRPS TGKIVNELFK EAREHGAVPL NEATRASGDD KSKSFTGGGY
   121  RLGSSFCKRS EYIYGENQLQ DVQILLKLWS NGFSLDDGEL RPYNEPTNAQ FLESVKRGEI
   181  PLELQRLVHG GQVNLDMEDH QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED
   241  KSILNAVVLI DDSVPTTKIQ IRLADGSRLI QRFNSTHRIL DVRNFIVQSR PEFAALDFIL
   301  VTSFPNKELT DESLTLLEAD ILNTVLLQQL K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

liver: 18 nTPM
cerebellum: 17 nTPM
parathyroid gland: 15 nTPM
kidney: 15 nTPM
bone marrow: 15 nTPM
cerebral cortex: 14 nTPM

Single-cell type

neutrophils: 908 nCPM
neutrophil progenitors: 146 nCPM
late spermatids: 100 nCPM
monocytes: 89 nCPM
lactotrophs: 71 nCPM
microglia: 68 nCPM

Immune cell

neutrophil: 43 nTPM
eosinophil: 18 nTPM
basophil: 16 nTPM
non-classical monocyte: 13 nTPM
classical monocyte: 12 nTPM
intermediate monocyte: 11 nTPM

Brain region

cerebellum: 33 nTPM
white matter: 31 nTPM
cerebral cortex: 28 nTPM
hippocampal formation: 27 nTPM
medulla oblongata: 27 nTPM
basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.1
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN2B as an antibody target. Whether an autoantibody or antibody against UBXN2B could matter depends on whether native UBXN2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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