Seroatlas · Human Serome Atlas

VASH1

Tubulinyl-Tyr carboxypeptidase 1

Also known as: KIAA1036, VASH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L8A9
Gene
VASH1
Ensembl
ENSG00000071246
Chromosome
14
Canonical length
365 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Centrosome,Basal body,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell proliferation; negative regulation of lymphangiogenesis; and regulation of cellular senescence. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q7L8A9|VASH1
     1  MPGGKKVAGG GSSGATPTSA AATAPSGVRR LETSEGTSAQ RDEEPEEEGE EDLRDGGVPF
    61  FVNRGGLPVD EATWERMWKH VAKIHPDGEK VAQRIRGATD LPKIPIPSVP TFQPSTPVPE
   121  RLEAVQRYIR ELQYNHTGTQ FFEIKKSRPL TGLMDLAKEM TKEALPIKCL EAVILGIYLT
   181  NSMPTLERFP ISFKTYFSGN YFRHIVLGVN FAGRYGALGM SRREDLMYKP PAFRTLSELV
   241  LDFEAAYGRC WHVLKKVKLG QSVSHDPHSV EQIEWKHSVL DVERLGRDDF RKELERHARD
   301  MRLKIGKGTG PPSPTKDRKK DVSSPQRAQS SPHRRNSRSE RRPSGDKKTS EPKAMPDLNG
   361  YQIRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VASH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • retina: 63 nTPM
  • spinal cord: 37 nTPM
  • heart muscle: 31 nTPM
  • midbrain: 28 nTPM
  • hippocampal formation: 23 nTPM
  • amygdala: 20 nTPM

Single-cell type

  • cone photoreceptor cells: 273 nCPM
  • rod photoreceptor cells: 273 nCPM
  • microglia: 226 nCPM
  • early spermatids: 141 nCPM
  • late spermatids: 131 nCPM
  • granulosa cells: 62 nCPM

Immune cell

  • non-classical monocyte: 2.7 nTPM
  • plasmacytoid DC: 2.4 nTPM
  • intermediate monocyte: 2 nTPM
  • myeloid DC: 1.3 nTPM
  • classical monocyte: 0.8 nTPM
  • gdT-cell: 0.6 nTPM

Brain region

  • medulla oblongata: 62 nTPM
  • spinal cord: 59 nTPM
  • midbrain: 56 nTPM
  • thalamus: 56 nTPM
  • pons: 56 nTPM
  • white matter: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.33
gnomAD missense Z
1.45
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VASH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VASH1 as an antibody target. Whether an autoantibody or antibody against VASH1 could matter depends on whether native VASH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VASH1 is annotated as secreted, so native VASH1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VASH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VASH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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