SVBP
Small vasohibin-binding protein
Also known as: CCDC23, MGC45441, SVBP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N300
- Gene
- SVBP
- Ensembl
- ENSG00000177868
- Chromosome
- 1
- Canonical length
- 66 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies,Cytosol
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Enables microtubule binding activity and peptidase activator activity. Involved in axon development; proteolysis; and regulation of metallopeptidase activity. Acts upstream of or within negative regulation of endothelial cell migration; negative regulation of protein ubiquitination; and protein secretion. Located in apical part of cell. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
66 residues, UniProt reviewed canonical sequence.
>Q8N300|SVBP
1 MDPPARKEKT KVKESVSRVE KAKQKSAQQE LKQRQRAEIY ALNRVMTELE QQQFDEFCKQ
61 MQPPGELocalizationUniProt · AlphaFold · HPA
Whether an antibody against SVBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 45 nTPM
Expression across tissuesHPA
Tissue
- testis: 45 nTPM
- thymus: 45 nTPM
- bone marrow: 41 nTPM
- ovary: 40 nTPM
- spinal cord: 39 nTPM
- amygdala: 33 nTPM
Single-cell type
- late primary spermatocytes: 207 nCPM
- differentiating spermatogonia: 159 nCPM
- oocytes: 147 nCPM
- early spermatids: 147 nCPM
- undifferentiated spermatogonia: 142 nCPM
- early primary spermatocytes: 140 nCPM
Immune cell
- T-reg: 116 nTPM
- eosinophil: 77 nTPM
- neutrophil: 71 nTPM
- basophil: 61 nTPM
- naive B-cell: 60 nTPM
- memory B-cell: 57 nTPM
Brain region
- white matter: 23 nTPM
- cerebellum: 21 nTPM
- medulla oblongata: 20 nTPM
- hypothalamus: 19 nTPM
- spinal cord: 19 nTPM
- midbrain: 18 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about SVBP.
Disease | AllUniProt
Conditions SVBP is implicated in, by any mechanism.
- Neurodevelopmental disorder with ataxia, hypotonia, and microcephaly (NEDAHM) MIM:618569
Disease | GeneticClinVar
6 pathogenic / likely-pathogenic of 19 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Neurodevelopmental disorder with ataxia, hypotonia, and microcephaly
- Lower limb spasticity
- Microcephaly
- Intellectual disability
- Neurodevelopmental disorder with ataxia
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.88
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.29
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- axon development
- negative regulation of endothelial cell migration
- negative regulation of protein ubiquitination
- protein secretion
- proteolysis
- regulation of metallopeptidase activity
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Small vasohibin-binding protein
- Coiled-coil domain-containing protein 23
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SVBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SVBP as an antibody target. Whether an autoantibody or antibody against SVBP could matter depends on whether native SVBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SVBP is annotated as secreted, so native SVBP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SVBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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