Seroatlas · Human Serome Atlas

UNC93A

Protein unc-93 homolog A

Also known as: dJ366N23.1, dJ366N23.2, UN93A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WB7
Gene: UNC93A
Ensembl: ENSG00000112494
Chromosome: 6
Canonical length: 457 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>Q86WB7|UNC93A
     1  MDRSLRNVLV VSFGFLLLFT AYGGLQSLQS SLYSEEGLGV TALSTLYGGM LLSSMFLPPL
    61  LIERLGCKGT IILSMCGYVA FSVGNFFASW YTLIPTSILL GLGAAPLWSA QCTYLTITGN
   121  THAEKAGKRG KDMVNQYFGI FFLIFQSSGV WGNLISSLVF GQTPSQETLP EEQLTSCGAS
   181  DCLMATTTTN STQRPSQQLV YTLLGIYTGS GVLAVLMIAA FLQPIRDVQR ESEGEKKSVP
   241  FWSTLLSTFK LYRDKRLCLL ILLPLYSGLQ QGFLSSEYTR SYVTCTLGIQ FVGYVMICFS
   301  ATDALCSVLY GKVSQYTGRA VLYVLGAVTH VSCMIALLLW RPRADHLAVF FVFSGLWGVA
   361  DAVWQTQNNA LYGVLFEKSK EAAFANYRLW EALGFVIAFG YSMFLCVHVK LYILLGVLSL
   421  TMVAYGLVEC VESKNPIRPH APGQVNQAED EEIQTKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC93A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

skin: 18 nTPM
liver: 13 nTPM
duodenum: 9 nTPM
esophagus: 4.8 nTPM
small intestine: 3.1 nTPM
cervix: 1.1 nTPM

Single-cell type

esophageal apical cells: 38 nCPM
oocytes: 37 nCPM
renal collecting duct principal cells: 36 nCPM
esophageal suprabasal cells: 8.6 nCPM
hepatocytes: 5.5 nCPM
fallopian tube ciliated cells: 5.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: -0.53
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNC93A as an antibody target. Whether an autoantibody or antibody against UNC93A could matter depends on whether native UNC93A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNC93A is annotated at the cell surface, where native UNC93A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label UNC93A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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