Seroatlas · Human Serome Atlas

TXNDC8

Thioredoxin domain-containing protein 8

Also known as: bA427L11.2, SPTRX-3, TRX6, TXND8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6A555
Gene
TXNDC8
Ensembl
ENSG00000204193
Chromosome
9
Canonical length
127 aa
Protein class
Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

Involved in spermatogenesis. Located in Golgi apparatus. Biomarker of male infertility. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>Q6A555|TXNDC8
     1  MVQIIKDTNE FKTFLTAAGH KLAVVQFSSK RCGPCKRMFP VFHAMSVKYQ NVFFANVDVN
    61  NSPELAETCH IKTIPTFQMF KKSQKVTLFS RIKRIICCYR SGFMSNLIFE FCGADAKKLE
   121  AKTQELM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXNDC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • testis: 18 nTPM
  • thymus: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 918 nCPM
  • early spermatids: 473 nCPM
  • late primary spermatocytes: 227 nCPM
  • sertoli cells: 6.7 nCPM
  • hepatic stellate cells: 6.5 nCPM
  • respiratory ciliated cells: 6.4 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • midbrain: 0.3 nTPM
  • pons: 0.3 nTPM
  • thalamus: 0.3 nTPM
  • amygdala: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0.01
gnomAD missense Z
-0.41
DepMap mean gene effect
-0.06
DepMap dependency class
none

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXNDC8 as an antibody target. Whether an autoantibody or antibody against TXNDC8 could matter depends on whether native TXNDC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXNDC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXNDC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TXNDC8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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